CD180 抗体
(3 references)-
- 抗原 See all CD180 抗体
- CD180 (CD180 Molecule (CD180))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This CD180 antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
- 特异性
- The mouse monoclonal antibody G28-8 recognizes an extracellular epitope of CD180, a 95-105 kDa TLR-like glycoprotein expressed on peripheral blood monocytes and dendritic cells, mantle zone B cells and marginal zone B cells, but very weakly on germinal center B cells.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
- 免疫原
- Human tonsillar B cells
- 克隆位点
- G28-8
- 亚型
- IgG1 kappa
-
anti-CD180 Molecule (CD180) antibody
CD180 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal G28-8 unconjugated
anti-CD180 Molecule (CD180) (Internal Region) antibodyCD180 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD180 Molecule (CD180) antibody (APC)CD180 适用: 人 FACS 宿主: 小鼠 Monoclonal G28-8 APC
anti-CD180 Molecule (CD180) antibody (PE)CD180 适用: 人 FACS 宿主: 小鼠 Monoclonal G28-8 PE
anti-CD180 Molecule (CD180) antibodyCD180 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD180 Molecule (CD180) (N-Term) antibodyCD180 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-CD180 Molecule (CD180) (C-Term) antibodyCD180 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-CD180 Molecule (CD180) (Internal Region) antibodyCD180 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Functional application: Induction of B cell proliferation.
Flow cytometry: Recommended dilution: 2 μg/mL. - 限制
- 仅限研究用
-
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
-
-
: "Caspase activity is required for stimulated B lymphocytes to enter the cell cycle." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6065-72, (2003) (PubMed).
: "Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 143, Issue 12, pp. 3873-80, (1990) (PubMed).
: "Antibody to a novel 95-kDa surface glycoprotein on human B cells induces calcium mobilization and B cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 12, pp. 4071-8, (1988) (PubMed).
-
: "Caspase activity is required for stimulated B lymphocytes to enter the cell cycle." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6065-72, (2003) (PubMed).
-
- 抗原
- CD180 (CD180 Molecule (CD180))
- 别名
- CD180 (CD180 产品)
- 别名
- Ly78 antibody, CD180 antibody, LY64 antibody, RP105 antibody, F630107B15 antibody, CD180 molecule antibody, CD180 antigen antibody, Cd180 antibody, CD180 antibody
- 背景
- CD180 Molecule,CD180, also known as RP105 (or Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. Its cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size.,LY64, Ly78, RP105, Bgp95
- 基因ID
- 4064
- UniProt
- Q99467
- 途径
- Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
-
