(2 references)-
- 抗原 See all PVRL2 抗体
- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PVRL2 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody R2.525 recognizes an extracellular epitope on CD112, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- NIH/3T3 cells transfected with human Nectin-2
- 克隆位点
- R2-525
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product PVRL2 Primary Antibody
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anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 76-353) antibody
PVRL2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) antibodyPVRL2 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2A6-2C1 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 58-212) antibodyPVRL2 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 4A11B12 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 251-350) antibodyPVRL2 适用: 人 WB, FACS, ELISA, ICC, IHC (fro), IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 83-291) antibodyPVRL2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) antibodyPVRL2 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) antibodyPVRL2 适用: 人 FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal R2-525 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 1-479) antibodyPVRL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) antibodyPVRL2 适用: 人 FACS, ELISA, IP 宿主: 小鼠 Monoclonal B-C12 unconjugated
anti-Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2) (AA 76-353) antibodyPVRL2 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C6 unconjugated
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain." in: The Journal of biological chemistry, Vol. 289, Issue 10, pp. 6969-77, (2014) (PubMed).
: "Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 7, pp. 3546-54, (2011) (PubMed).
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: "CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain." in: The Journal of biological chemistry, Vol. 289, Issue 10, pp. 6969-77, (2014) (PubMed).
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- 抗原
- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
- 别名
- CD112 (PVRL2 产品)
- 别名
- prr2 antibody, AI325026 antibody, AI987993 antibody, Cd112 antibody, MPH antibody, Pvr antibody, Pvs antibody, nectin-2 antibody, CD112 antibody, HVEB antibody, PRR2 antibody, PVRR2 antibody, nectin cell adhesion molecule 2 antibody, Nectin2 antibody, NECTIN2 antibody
- 背景
- Nectin cell adhesion molecule 2,CD112, also known as nectin-2, is a transmembrane glycoprotein involved in organization of adherens junctions. It also serves as a target molecule for entry of certain strains of herpes simplex virus (HSV) and pseudorabies virus (PRV). It is homologous to CD155, which serves as a target molecule for polio virus. CD112 seems to play a role in neural tube formation, with N-cadherin. Inside the cell, CD112 is connected with actin cytoskeleton through afadin. Variations in the CD112 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.,NECTIN2, HVEB, PRR2, PVRL2, PVRR2
- 基因ID
- 5819
- UniProt
- Q92692
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
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