TNFRSF4 抗体
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- 抗原 See all TNFRSF4 抗体
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
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适用
- 人, Non-Human Primate
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TNFRSF4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells.
- 交叉反应 (详细)
- Human, Non-Human Primates
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- HTLV 1-transformed HUT-102 cells
- 克隆位点
- Ber-ACT35
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product TNFRSF4 Primary Antibody
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- 应用备注
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Flow cytometry: Recommended dilution: 3-6 μg/mL.
Immunohistochemistry: Recommended dilution: 5-10 μg/mL. - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 7, pp. 3641-50, (2013) (PubMed).
: "Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells." in: Journal of leukocyte biology, Vol. 82, Issue 3, pp. 576-84, (2007) (PubMed).
: "Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus." in: Journal of virology, Vol. 80, Issue 7, pp. 3386-94, (2006) (PubMed).
: "The effect of anti-human CD134 monoclonal antibody on phytohemagglutinin-induced mRNA expression of perforin in peripheral blood mononuclear cells." in: Cellular & molecular immunology, Vol. 2, Issue 6, pp. 467-71, (2006) (PubMed).
: "Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes." in: Diabetes, Vol. 55, Issue 1, pp. 50-60, (2005) (PubMed).
: "Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 11, Issue 8, pp. 1426-38, (2000) (PubMed).
: "The T-cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T-cell lymphoma." in: Blood, Vol. 93, Issue 10, pp. 3487-93, (1999) (PubMed).
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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 7, pp. 3641-50, (2013) (PubMed).
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- 抗原
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- 别名
- CD134 (TNFRSF4 产品)
- 别名
- TNFRSF4 antibody, ACT35 antibody, CD134 antibody, Ly-70 antibody, Ox40 antibody, TXGP1L antibody, Txgp1 antibody, OX40 antibody, TNF receptor superfamily member 4 antibody, tumor necrosis factor receptor superfamily, member 4 antibody, TNFRSF4 antibody, Tnfrsf4 antibody
- 背景
- TNF receptor superfamily member 4,CD134 (TNFRSF4, also known as OX40) is a type I transmembrane glycoprotein of TNF/NGF receptor family expressed on activated T cells, fibroblasts, and hematopoietic precursors. Binding to its ligand (OX40L, TNFSF4) on antigen presenting cells gives to the T cell costimulatory signal, and this interaction results also in B cell proliferation and influences T cell memory pool. CD134 is upregulated at sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.,TNFRSF4, OX40, ACT35, IMD16, TXGP1L
- 基因ID
- 7293
- UniProt
- P43489
- 途径
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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