(4 references)-
- 抗原 See all CD70 抗体
- CD70 (CD70 Molecule (CD70))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD70 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- human L428 cell line
- 克隆位点
- Ki-24
- 亚型
- IgG3 kappa
- Top Product
- Discover our top product CD70 Primary Antibody
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anti-CD70 Molecule (CD70) (AA 39-193) antibody
CD70 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibodyCD70 适用: 人 FACS 宿主: 小鼠 Monoclonal Ki-24 unconjugated
anti-CD70 Molecule (CD70) (AA 47-191) antibodyCD70 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibodyCD70 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) (AA 1-193) antibodyCD70 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibodyCD70 适用: 人 WB, FACS 宿主: 兔 Monoclonal unconjugated
anti-CD70 Molecule (CD70) (AA 72-101) antibodyCD70 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) (AA 64-192) antibodyCD70 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD70 Molecule (CD70) antibody (PerCP-Cy5.5)CD70 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal FR70 PerCP-Cy5.5
anti-CD70 Molecule (CD70) (AA 31-80) antibodyCD70 适用: 人, Cow, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants." in: Cell death & disease, Vol. 5, pp. e1035, (2014) (PubMed).
: "The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans." in: International immunology, Vol. 21, Issue 8, pp. 891-904, (2009) (PubMed).
: "Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6940-7, (2005) (PubMed).
: "Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody." in: Journal of virology, Vol. 75, Issue 11, pp. 5215-21, (2001) (PubMed).
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: "CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants." in: Cell death & disease, Vol. 5, pp. e1035, (2014) (PubMed).
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- 抗原
- CD70 (CD70 Molecule (CD70))
- 别名
- CD70 (CD70 产品)
- 背景
- CD70 Molecule,CD70, also known as TNFSF7 or CD27L, is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.,CD27L, TNFSF7, CD27 ligand, TNLG8A
- 基因ID
- 970
- UniProt
- P32970
- 途径
- Cancer Immune Checkpoints
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