(2 references)-
- 抗原 See all CD42b (GP1BA) 抗体
- CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD42b antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody AK2 recognizes an extracellular epitope of CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c, 160 kDa), CD42b/c forms a noncovalent complex with CD42a and CD42d.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- Human platelets
- 克隆位点
- AK2
- 亚型
- IgG1
- Top Product
- Discover our top product GP1BA Primary Antibody
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anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) (AA 17-183) antibody
GP1BA 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 6H6B11 unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) (AA 19-291) antibodyGP1BA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibodyGP1BA 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) (AA 19-128) antibodyGP1BA 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C6 unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibodyGP1BA 适用: 人 FACS, WB, ELISA, IP, ICC 宿主: 小鼠 Monoclonal AK2 unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibodyGP1BA 适用: 人 FACS, WB, ELISA, IP, ICC 宿主: 小鼠 Monoclonal AK2 unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibodyGP1BA 适用: 人, Non-Human Primate FACS, IHC (fro) 宿主: 小鼠 Monoclonal HIP1 unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) (AA 17-282) antibodyGP1BA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) (AA 1-626) antibodyGP1BA 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) antibodyGP1BA 适用: 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse." in: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014) (PubMed).
: "Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome ..." in: Haematologica, Vol. 93, Issue 11, pp. 1743-7, (2008) (PubMed).
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: "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse." in: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014) (PubMed).
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- 抗原
- CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
- 别名
- CD42b (GP1BA 产品)
- 背景
- Glycoprotein Ib platelet subunit alpha,CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.,BSS, GP1B, VWDP, CD42B, GPIbA, BDPLT1, BDPLT3, DBPLT3
- 基因ID
- 2811
- UniProt
- P07359
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