(6 references)-
- 抗原 See all CD79b (CD79B) 抗体
- CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD79b antibody is conjugated to APC
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- Fraction of Ig-associated molecules isolated from Ramos B cells
- 克隆位点
- CB3-1
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product CD79B Primary Antibody
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anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-159) antibody
CD79B 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 1-229) antibodyCD79B 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 4E10-2A10 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (C-Term) antibodyCD79B 适用: 人 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal B29-123 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody (FITC)CD79B 适用: 人 FACS 宿主: 小鼠 Monoclonal CB3-1 FITC
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibody (PE)CD79B 适用: 人 FACS 宿主: 小鼠 Monoclonal CB3-1 PE
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-229) antibodyCD79B 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) antibodyCD79B 适用: 人 FACS, WB, IP, IHC 宿主: 小鼠 Monoclonal CB3-1 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 30-160) antibodyCD79B 适用: 人 FACS, WB, IHC, ELISA, ICC, Neut 宿主: 小鼠 Monoclonal 4H6A3 unconjugated
anti-CD79b Molecule, Immunoglobulin-Associated beta (CD79B) (AA 29-159) antibodyCD79B 适用: 人 IHC, ELISA, Coat, StM 宿主: 兔 Monoclonal IGB-3170R unconjugated Recombinant Antibody
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." in: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).
: "In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates." in: Molecular cancer therapeutics, Vol. 8, Issue 10, pp. 2937-46, (2009) (PubMed).
: "New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders." in: Journal of clinical pathology, Vol. 55, Issue 3, pp. 180-3, (2002) (PubMed).
: "CD79b expression in B-cell chronic lymphocytic leukemia." in: Haematologica, Vol. 85, Issue 5, pp. 556-7, (2000) (PubMed).
: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).
: "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8522-6, (1992) (PubMed).
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: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." in: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).
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- 抗原
- CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
- 别名
- CD79b (CD79B 产品)
- 别名
- B29 antibody, Ig-beta antibody, Igb antibody, Igbeta antibody, AGM6 antibody, IGB antibody, CD79B antigen antibody, CD79b molecule antibody, Cd79b antibody, CD79B antibody
- 背景
- CD79b molecule,CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR beta, Ig-beta, B29, IGB
- 基因ID
- 974
- UniProt
- P40259
- 途径
- BCR Signaling
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