(4 references)-
- 抗原 See all CCR5 抗体
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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抗原表位
- AA 1-22
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CCR5 antibody is conjugated to APC
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody T21/8 recognizes an extracellular epitope on the N-teminus of CD195, an approximately 45 kDa G-protein coupled receptor 1 family protein expressed on resting T cells, monocytes, macrophages, and immature dendritic cells.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- CCR5 peptide (Met1-Lys22) KLH conjugate
- 克隆位点
- T21-8
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product CCR5 Primary Antibody
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anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibody
CCR5 适用: 人 IHC (fro) 宿主: 小鼠 Monoclonal 12D1 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibodyCCR5 适用: 人 WB, ELISA, FACS, IHC 宿主: 小鼠 Monoclonal 6G11D1 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 19-34), (N-Term) antibodyCCR5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) antibodyCCR5 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6H3D5 unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 201-300) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 151-200) antibodyCCR5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) antibodyCCR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-352) antibodyCCR5 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (pSer336) antibodyCCR5 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 5 (CCR5) (AA 1-22) antibodyCCR5 适用: 人 WB, ELISA, FACS, IP, ICC 宿主: 小鼠 Monoclonal T21-8 unconjugated
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 409-13, (2012) (PubMed).
: "Gp120 V3-dependent impairment of R5 HIV-1 infectivity due to virion-incorporated CCR5." in: The Journal of biological chemistry, Vol. 282, Issue 51, pp. 36923-32, (2007) (PubMed).
: "G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37503-15, (2005) (PubMed).
: "Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2190-8, (2003) (PubMed).
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: "Single Particle Tracking reveals two distinct environments for CD4 receptors at the surface of living T lymphocytes." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 409-13, (2012) (PubMed).
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- 抗原
- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
- 别名
- CD195 / CCR5 (CCR5 产品)
- 别名
- CC-CKR-5 antibody, CCCKR5 antibody, CCR-5 antibody, CD195 antibody, CKR-5 antibody, CKR5 antibody, CMKBR5 antibody, IDDM22 antibody, Ckr5 antibody, Cmkbr5 antibody, CCR1-L antibody, GPCR antibody, CCR5 antibody, AM4-7 antibody, C-C motif chemokine receptor 5 (gene/pseudogene) antibody, chemokine (C-C motif) receptor 5 antibody, C-C motif chemokine receptor 5 antibody, CCR5 antibody, Ccr5 antibody
- 背景
- C-C motif chemokine receptor 5,CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.,CKR5, CCR5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
- 基因ID
- 1234
- UniProt
- P51681
- 途径
- Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size
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