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TCR alpha/beta 抗体 (PE)

TCR alpha/beta 适用: 大鼠, Non-Human Primate FACS 宿主: 小鼠 Monoclonal R73 PE
产品编号 ABIN2749096
发货至: 中国
  • 抗原 See all TCR alpha/beta products
    TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))
    适用
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    大鼠, Non-Human Primate
    宿主
    • 30
    • 12
    小鼠
    克隆类型
    • 42
    单克隆
    标记
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    • 9
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    This TCR alpha/beta antibody is conjugated to PE
    应用范围
    • 41
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    • 12
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    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal R73 recognizes an extracellular epitope TCR alpha/beta, the dominant subtype of T cell receptor expressed in peripheral blood.
    交叉反应 (详细)
    Non-Human Primates, Rat
    纯化方法
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    Rat T blasts and erythrocytes
    克隆位点
    R73
    亚型
    IgG1 kappa
  • 应用备注
    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    说明

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Fuller, Bogdani, Tupling, Jensen, Pefley, Manavi, Cort, Blankenhorn, Mordes, Lernmark, Kwitek: "Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene." in: Physiological genomics, Vol. 38, Issue 1, pp. 89-97, (2009) (PubMed).

    Müller, van den Brandt, Odoardi, Tischner, Herath, Flügel, Reichardt: "A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats." in: The Journal of clinical investigation, Vol. 118, Issue 4, pp. 1405-16, (2008) (PubMed).

    Radojevic, Arsenovic-Ranin, Kosec, Pesic, Pilipovic, Perisic, Plecas-Solarovic, Leposavic: "Neonatal castration affects intrathymic kinetics of T-cell differentiation and the spleen T-cell level." in: The Journal of endocrinology, Vol. 192, Issue 3, pp. 669-82, (2007) (PubMed).

    Shao, Sun, Kaplan, Sun: "Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 4, pp. 2849-54, (2004) (PubMed).

    Kerstan, Hünig: "Cutting edge: distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 3, pp. 1341-5, (2004) (PubMed).

    Li, Thanikachalam, Pang, Kawaharada, Aitouche, Pham: "A clinically relevant CTLA4-Ig-based regimen induces chimerism and tolerance to heart grafts." in: The Annals of thoracic surgery, Vol. 72, Issue 4, pp. 1306-10, (2001) (PubMed).

    Ritter, Schröder, Risch, Vergopoulos, Shean, Kolls, Brock, Lehmann, Volk: "Ischemia/reperfusion injury-mediated down-regulation of adenovirus-mediated gene expression in a rat heart transplantation model is inhibited by co-application of a TNFRp55-Ig chimeric construct." in: Gene therapy, Vol. 7, Issue 14, pp. 1238-43, (2000) (PubMed).

    Carlson, Jansson, Larsson, Bucht, Lorentzen: "The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats." in: The American journal of pathology, Vol. 156, Issue 6, pp. 2057-65, (2000) (PubMed).

    Wilhelm, Pratschke, Beato, Taal, Kusaka, Hancock, Tilney: "Activation of the heart by donor brain death accelerates acute rejection after transplantation." in: Circulation, Vol. 102, Issue 19, pp. 2426-33, (2000) (PubMed).

    Kraus, Lambracht, Wonigeit, Hünig: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).

    Hünig, Wallny, Hartley, Lawetzky, Tiefenthaler: "A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes." in: The Journal of experimental medicine, Vol. 169, Issue 1, pp. 73-86, (1989) (PubMed).

  • 抗原
    TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))
    别名
    TCR alpha/beta (TCR alpha/beta 产品)
    背景
    The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.,TCRA/B
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