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CD79a 抗体 (AA 208-222)

Name: CD79a 抗体 (AA 208-222)
Brand: antibodies-online
SKU: ABIN2749074
Availability: OutOfStock

CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 马, 兔, 豚鼠, 犬, Non-Human Primate FACS, WB, IHC (p), IP 宿主: 小鼠 Monoclonal HM47 unconjugated

Western blotting analysis of human CD79a using mouse monoclonal antibody HM47 on lysates of Raji and Jurkat (negative control) cell line under reducing and non-reducing conditions. (CD79a 抗体 (AA 208-222))

Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human CD79a (HM47) purified antibody (concentration in sample 4 μg/mL, GAM APC). (CD79a 抗体 (AA 208-222))

FACS

Separation of human CD79a positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD79a (HM47) purified antibody (concentration in sample 4 μg/mL, GAM APC). (CD79a 抗体 (AA 208-222))

FACS

3 images

(7 references)

产品编号 ABIN2749074

发货至: 中国

Datasheet as PDF

抗原 See all CD79a (CD79A) 抗体

CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
抗原表位
69

26

10

8

8

7

6

6

5

5

5

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 208-222
适用
177

89

73

52

51

34

28

26

26

26

16

10

5

3

2

2

2

2

1
人, 小鼠, 大鼠, Cow, Pig, 小鸡, 马, 兔, 豚鼠, 犬, Non-Human Primate
宿主
96

93

1
小鼠
Compatible Secondaries
克隆类型
116

73

1
单克隆
标记
88

18

14

14

13

7

5

5

5

5

5

5

1

1

1

1

1

1
This CD79a antibody is un-conjugated
应用范围
112

91

61

57

48

22

20

12

9

5

5

3

2

1

1

1

1
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

特异性

The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.

交叉反应（详细）

Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Canine (Dog), Equine (Horse), Guinea pig, Rabbit, Chicken

纯化方法

Purified by protein-A affinity chromatography.

纯度

> 95 % (by SDS-PAGE)

免疫原

Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a

克隆位点

HM47

亚型

IgG1 kappa

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anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibody
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anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 33-145) antibody
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anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) antibody
CD79A 适用: 人 FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal rIGA-764 unconjugated Recombinant Antibody

anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibody (FITC)
CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 马, 兔, 豚鼠, Opossum FACS 宿主: 小鼠 Monoclonal HM57 FITC

anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibody
CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 马, 兔, 豚鼠, Opossum FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal HM57 unconjugated

anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibody (PE)
CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 马, 兔, 豚鼠, Opossum FACS 宿主: 小鼠 Monoclonal HM57 PE

anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 208-222) antibody (PE)
CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 马, 兔, 豚鼠, 犬, Non-Human Primate FACS 宿主: 小鼠 Monoclonal HM47 PE

anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 70-142) antibody
CD79A 适用: 人 IF, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

Flow cytometry: Recommended dilution: 1-4 μg/mL, intracellular staining.
Western blotting: Recommended dilution: 1-2 μg/mL.

限制

仅限研究用
浓度

1 mg/mL

缓冲液

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store at 2-8°C. Do not freeze.
Zhao, Hassan, Perry, Ning, Stass, Dehner: "C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." in: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).

Bhargava, Kallakury, Ross, Azumi, Bagg: "CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner." in: American journal of clinical pathology, Vol. 128, Issue 2, pp. 306-13, (2007) (PubMed).

Fernandez, West, Jackson, Kidney: "Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors." in: Veterinary pathology, Vol. 42, Issue 4, pp. 437-45, (2005) (PubMed).

Islas-Ohlmayer, Padgett-Thomas, Domiati-Saad, Melkus, Cravens, Martin, Netto, Garcia: "Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus." in: Journal of virology, Vol. 78, Issue 24, pp. 13891-900, (2004) (PubMed).

Torlakovic, Torlakovic: "B-cell markers in lymphocyte predominance Hodgkin disease." in: Archives of pathology & laboratory medicine, Vol. 126, Issue 7, pp. 862-3, (2002) (PubMed).

Rassenti, Kipps: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).

Mason, Cordell, Tse, van Dongen, van Noesel, Micklem, Pulford, Valensi, Comans-Bitter, Borst: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).
抗原

CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

别名

CD79a (CD79A 产品)

别名

CD79A antibody, Ig-alpha antibody, Iga antibody, Igalpha antibody, Ly-54 antibody, Ly54 antibody, mb-1 antibody, IGA antibody, MB-1 antibody, IG-alpha antibody, CD79a molecule antibody, CD79A antigen (immunoglobulin-associated alpha) antibody, Cd79a molecule-like antibody, CD79A antibody, Cd79a antibody, Cd79al antibody

背景

CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA

基因ID

973

UniProt

P11912

途径

BCR Signaling