PTPRJ 抗体 (AA 1-444) (Biotin)
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- 抗原 See all PTPRJ 抗体
- PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))
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抗原表位
- AA 1-444
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PTPRJ antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody MEM-CD148/05 recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
- 交叉反应 (详细)
- Human
- 纯化方法
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
- 免疫原
- Human recombinant CD148 (amino acids 1-444)
- 克隆位点
- MEM-CD148-05
- 亚型
- IgG2b
- Top Product
- Discover our top product PTPRJ Primary Antibody
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- 应用备注
- Flow cytometry: Recommended dilution: 1-12 μg/mL.
- 说明
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The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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- 抗原
- PTPRJ (Protein tyrosine Phosphatase, Receptor Type, J (PTPRJ))
- 别名
- CD148 (PTPRJ 产品)
- 别名
- HAAP antibody, CD148 antibody, DEP1 antibody, HPTPeta antibody, R-PTP-ETA antibody, SCC1 antibody, AI450271 antibody, BET antibody, Byp antibody, DEP-1 antibody, PTPbeta2 antibody, Ptpb2 antibody, RPTPJ antibody, Scc-1 antibody, Scc1 antibody, PTPRJ antibody, acid phosphatase 1 antibody, protein tyrosine phosphatase, receptor type J antibody, protein tyrosine phosphatase, receptor type, J antibody, ACP1 antibody, PTPRJ antibody, Ptprj antibody, EUBREC_2762 antibody
- 背景
- Protein tyrosine phosphatase receptor type J,CD148 (also known as HPTP-eta or DEP-1) is a transmembrane protein tyrosin phosphatase, containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leucocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.,HPTP-eta, DEP-1, PTPRJ, DEP1, SCC1, HPTPeta, R-PTP-ETA
- 基因ID
- 5795
- UniProt
- Q12913
- 途径
- EGFR Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
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