CTLA4 抗体
(4 references)-
- 抗原 See all CTLA4 抗体
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CTLA4 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- The mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
- 免疫原
- Human CD152-IgG heavy chain fusion protein
- 克隆位点
- BNI3
- 亚型
- IgG2a
- Top Product
- Discover our top product CTLA4 Primary Antibody
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anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-135) antibody
CTLA4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibody (PE)CTLA4 适用: 人 FACS 宿主: 小鼠 Monoclonal BNI3 PE
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-162) antibodyCTLA4 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 9D2E9 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibodyCTLA4 适用: 人 FACS, IP, ICC, IHC (fro) 宿主: 小鼠 Monoclonal BNI3 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) antibodyCTLA4 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM50 unconjugated Recombinant Antibody
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) antibodyCTLA4 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8B3F8 unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 75-170) antibodyCTLA4 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 41-90) antibodyCTLA4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 52-211) antibodyCTLA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibody (APC)CTLA4 适用: 人 FACS 宿主: 小鼠 Monoclonal BNI3 APC
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- 应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL, Intracellular staining.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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: "[The use of multi-color flow cytometry for identification of functional markers of nTregs in patients with severe asthma]." in: Pneumonologia i alergologia polska, Vol. 80, Issue 5, pp. 389-401, (2012) (PubMed).
: "Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands." in: BMC biotechnology, Vol. 7, pp. 51, (2007) (PubMed).
: "Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis." in: Clinical and experimental immunology, Vol. 126, Issue 1, pp. 143-50, (2001) (PubMed).
: "Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection." in: Clinical and experimental immunology, Vol. 115, Issue 3, pp. 451-7, (1999) (PubMed).
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: "[The use of multi-color flow cytometry for identification of functional markers of nTregs in patients with severe asthma]." in: Pneumonologia i alergologia polska, Vol. 80, Issue 5, pp. 389-401, (2012) (PubMed).
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- 抗原
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
- 别名
- CD152 (CTLA4 产品)
- 别名
- CTLA-4 antibody, CTLA4 antibody, CD152 antibody, Cd152 antibody, Ctla-4 antibody, Ly-56 antibody, CD antibody, CELIAC3 antibody, GRD4 antibody, GSE antibody, IDDM12 antibody, sCTLA4 antibody, cytotoxic T-lymphocyte associated protein 4 antibody, cytotoxic T-lymphocyte-associated protein 4 antibody, CTLA4 antibody, Ctla4 antibody
- 背景
- Cytotoxic T-lymphocyte associated protein 4,CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.,CTLA4, GSE, GRD4
- 基因ID
- 1493
- UniProt
- P16410
- 途径
- Cancer Immune Checkpoints
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