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Profilin 抗体 (full length)

PFN 适用: 人, Cow, 小鼠, Pig, 大鼠 WB, ICC, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2745561
发货至: 中国
  • 抗原 See all Profilin (PFN) 抗体
    Profilin (PFN)
    抗原表位
    • 8
    • 1
    full length
    适用
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    人, Cow, 小鼠, Pig, 大鼠
    宿主
    • 9
    • 2
    克隆类型
    • 9
    • 2
    多克隆
    标记
    • 5
    • 2
    • 2
    • 2
    This Profilin antibody is un-conjugated
    应用范围
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
    特异性
    Recognizes human, mouse, rat, pig, bovine and marsupial profilin.
    交叉反应
    牛, 人, 小鼠, 猪, 大鼠
    纯化方法
    Antigen affinity purified.
    组件
    Contains Positive Control: Human platelet protein (Prod. No. AG-35T-0001), 500μg supplied at 5mg/ml in SDS sample buffer. Use 5μl (25μg) per lane for Western blotting of tricine gels (13% acrylamide) or 15% Laemmli gels.
    免疫原
    Human full-length profilin.
    Top Product
    Discover our top product PFN Primary Antibody
  • 应用备注
    Use 5 μL (25 μg) per lane for Western blotting of tricine gels (13 % acrylamide) or 15 % Laemmli gels.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    In PBS containing 1 mg/mL BSA and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    有效期
    12 months
  • 抗原
    Profilin (PFN)
    别名
    Profilin (PFN 产品)
    别名
    LOC406154 antibody, GB13380 antibody, profilin antibody, PFN antibody, PRF antibody
    背景
    Profilin (PFN1) is a ubiquitous small (12-15 kDa) phosphoinositide and poly-L-proline binding protein that plays a role in signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties. Whereas profilin I appears to be highly expressed in most tissues except for skeletal muscle, profilin II is predominantly expressed in brain and at lower levels also in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes. Profilin binding to PIP2 interferes with PIP2 hydrolysis by soluble phospholipase C-gamma, an inhibition that can be overcome by tyrosine phosphorylation of PLC-gamma. Besides actin monomer sequestration and stimulation of actin nucleotide exchange, profilin can also promote cellular actin filament growth. Profilin is involved in the actin dependent intracellular motility of cytopathogenic bacteria, the regulation of cell adhesion and possibly also in linking the actin cytoskeleton and endocytosis. Profilin has been found to associate with defined complexes containing proteins such as Arp2/3 or the Rho/Rac pathways constituents ROCK-II and HEM2/NAP1. Defects in PFN1 are the cause of amyotrophic lateral sclerosis 18 (ALS18).
    UniProt
    P07737
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