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APAF1 抗体 (N-Term)
APAF1
适用: 小鼠, 大鼠
WB, ELISA, IP, ICC
宿主: 大鼠
Monoclonal
13F11
unconjugated
APAF1抗体详情
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抗原
See all APAF1 抗体
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
抗原表位
All epitopes for APAF1 抗体
AA 1-97, N-Term
适用
All reactivities for APAF1 抗体
小鼠, 大鼠
宿主
All hosts for APAF1 抗体
大鼠
克隆类型
All clonalities for APAF1 抗体
单克隆
标记
All conjugates for APAF1 抗体
This APAF1 antibody is un-conjugated
应用范围
All applications for APAF1 抗体
Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC)
特异性
Recognizes the CARD domain of mouse and rat Apaf-1.
交叉反应
小鼠, 大鼠
无交叉反应
人
交叉反应 (详细)
Does not cross-react with human Apaf-1.
纯度
>95 % (SDS-PAGE)
内毒素水平
<0.1EU/μg purified protein (LAL test, Lonza).
免疫原
Recombinant mouse Apaf-1 (aa 1-97) containing the N-terminal CARD domain.
克隆位点
13F11
亚型
IgG2a
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Discover our top product APAF1 Primary Antibody
Alternatives
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使用细节
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应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
Lot specific
缓冲液
In PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
有效期
12 months
APAF1目标详情
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抗原
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
别名
Apaf-1 (APAF1 产品 )
别名
APAF1 antibody, ARK antibody, Apaf-1 antibody, Apaf1 antibody, CG6829 antibody, D-Apaf-1 antibody, DARK antibody, Dapaf-1 antibody, Dapaf-1/HAC-1 antibody, Dark antibody, Dark/Apaf-I antibody, Dark/Dapaf-1/HAC1 antibody, Dark/Hac-1/dApaf-1 antibody, Dark/Hac-1/dApaf1 antibody, Dmel\\CG6829 antibody, Hac-1 antibody, Hac-1/Dark antibody, Hac1 antibody, T1 antibody, anon-53Fa antibody, apaf-1 antibody, apaf1 antibody, arc antibody, ark antibody, dAPAF-1 antibody, dApaf-1 antibody, dApaf-1/DARK/HAC-1 antibody, dApaf1 antibody, dArk antibody, dapaf antibody, dapaf-1 antibody, dapaf-1L antibody, dapaf-1S antibody, dark antibody, dark/dapaf-1/hac-1 antibody, dark/hac-1/dapaf-1 antibody, hac-1 antibody, hac1 antibody, l(2)SH0173 antibody, APAF-1 antibody, CED4 antibody, 6230400I06Rik antibody, Apaf1l antibody, fog antibody, mKIAA0413 antibody, zgc:136543 antibody, Death-associated APAF1-related killer antibody, apoptotic peptidase activating factor 1 L homeolog antibody, apoptotic peptidase activating factor 1 antibody, Dark antibody, apaf1.L antibody, apaf1 antibody, APAF1 antibody, Apaf1 antibody
背景
Apaf-1 is a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. It contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome, mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis.
UniProt
Q9EPV5
途径
p53 Pathway , Apoptosis , Caspase Cascade in Apoptosis , Tube Formation , Positive Regulation of Endopeptidase Activity
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