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Ubiquitin 抗体

Ubiquitin 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN271973
发货至: 中国
  • 抗原 See all Ubiquitin 抗体
    Ubiquitin
    适用
    • 141
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    • 66
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    人, 小鼠, 大鼠
    宿主
    • 100
    • 73
    • 3
    • 1
    • 1
    • 1
    克隆类型
    • 94
    • 85
    多克隆
    标记
    • 77
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    This Ubiquitin antibody is un-conjugated
    应用范围
    • 162
    • 90
    • 82
    • 60
    • 57
    • 42
    • 27
    • 21
    • 20
    • 14
    • 13
    • 9
    • 4
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This antibody detects endogenous levels of Ubiquitin protein.
    纯化方法
    Affinity Chromatography using epitope-specific immunogen.
    Top Product
    Discover our top product Ubiquitin Primary Antibody
  • 应用备注
    ELISA: 1/20000approx. 1/40000. Immunohistochemistry: 1/50-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Chen, Zhang, Chen, Bao, Wang, Zhu: "Electrical field stimulation induces cardiac fibroblast proliferation through the calcineurin-NFAT pathway." in: Canadian journal of physiology and pharmacology, Vol. 90, Issue 12, pp. 1611-22, (2012) (PubMed).

    Wang, Zhao, Qi, Gu, Rong, Mu, Zou, Tao, You, Guo: "Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP." in: Journal of cellular biochemistry, Vol. 112, Issue 2, pp. 509-19, (2011) (PubMed).

  • 抗原
    Ubiquitin
    别名
    Ubiquitin (Ubiquitin 产品)
    背景
    Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1, the activated ubiquitin is subsequently transfered to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue. The ubiquitin-proteasome pathway has been implicated in a wide range of normal biological processes and in disease-related abnormalities. Several proteins such as IkappaB, p53, cdc25a and Bcl-2 have been shown to be targets for the ubiquitination-proteosome process as part of regulation of cell cycle progression, differentiation, cell stress response and apoptosis.Synonyms: Polyubiquitin-B, UBB
    基因ID
    7314
    UniProt
    P0CG47
    途径
    Mitotic G1-G1/S Phases, Ubiquitin Proteasome Pathway
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