(6 references)-
- 抗原 See all PTCRA 抗体
- PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))
- 适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PTCRA antibody is un-conjugated
- 应用范围
- Immunoprecipitation (IP), Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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At very early stages in the intrathymic differentiation of T lymphocytes which will bear αβ T Cell Receptors (TCR), the TCR β chain forms a heterodimer with the pre-TCR α chain (pTα) to form the pre-TCR. This pre-TCR associates with the signal-transducing CD3 complex and controls the survival and proliferation of CD4- CD8- (DN) thymocytes, plays a role in allelic exclusion of the TCR β chain, directly or indirectly regulates TCR δ chain expression, and is eventually replaced by the TCR α chain as thymocytes mature. The 2F5 antibody reacts with the PTα on the surface of CD44- CD25-/lo DN thymocytes.
BD Pharmingen™ Purified Mouse Anti-Mouse Pre-T Cell Receptor α Chain - Purified - Clone 2F5 - Isotype Mouse IgG1, κ - Reactivity Ms - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Recombinant extracellular (Ig-like) domain of pTalpha
- 克隆位点
- 2F5
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product PTCRA Primary Antibody
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anti-Pre T-Cell Antigen Receptor alpha (PTCRA) (AA 172-281) antibody
PTCRA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Pre T-Cell Antigen Receptor alpha (PTCRA) (AA 197-225), (C-Term) antibodyPTCRA 适用: 人 WB 宿主: 兔 Polyclonal RB39212 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex." in: The Journal of experimental medicine, Vol. 190, Issue 1, pp. 141-4, (1999) (PubMed).
: "Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein." in: The Journal of experimental medicine, Vol. 190, Issue 8, pp. 1093-102, (1999) (PubMed).
: "Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?" in: Seminars in immunology, Vol. 11, Issue 4, pp. 251-62, (1999) (PubMed).
: "Pleiotropic changes controlled by the pre-T-cell receptor." in: Current opinion in immunology, Vol. 11, Issue 2, pp. 135-42, (1999) (PubMed).
: "On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment." in: Immunity, Vol. 9, Issue 5, pp. 649-55, (1998) (PubMed).
: "Structure and function of the pre-T cell receptor." in: Annual review of immunology, Vol. 15, pp. 433-52, (1997) (PubMed).
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: "Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex." in: The Journal of experimental medicine, Vol. 190, Issue 1, pp. 141-4, (1999) (PubMed).
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- 抗原
- PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))
- 别名
- Pre-T Cell Receptor alpha Chain (PTCRA 产品)
- 别名
- gp33 antibody, pT-alpha antibody, pT-alpha-TCR antibody, pT[a] antibody, pTa antibody, pTalpha antibody, PT-ALPHA antibody, PTA antibody, pre T cell antigen receptor alpha antibody, pre T-cell antigen receptor alpha antibody, Ptcra antibody, PTCRA antibody
- 背景
- Synonyms: pTα
- 途径
- Cancer Immune Checkpoints
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