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HLA-DM 抗体

HLA-DM 适用: 人 ICS 宿主: 小鼠 Monoclonal MaP-DM1 unconjugated
产品编号 ABIN2689553
发货至: 中国
  • 抗原
    HLA-DM (MHC Class II HLA-DM (HLA-DM))
    适用
    宿主
    • 1
    小鼠
    克隆类型
    • 1
    单克隆
    标记
    • 1
    This HLA-DM antibody is un-conjugated
    应用范围
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Intracellular Staining (ICS)
    品牌
    BD Pharmingen™
    产品特性
    Reacts with human leukocyte antigen-DM (HLA-DM), a non-classical MHC class II molecule expressed in the cytoplasm of antigen presenting cells (APC). HLA-DM is composed of alpha and beta subunits which form a similar structure as the classical class II molecules. HLA-DM catalyzes the dissociation of CLIP from MHC class II-CLIP complexes in vitro and facilitates the binding of antigenic peptides. It also prevents self-antigens from becoming stably complexed with class II molecules and being presented to T cells. Profile of intracellular staining of peripheral blood lymphocytes analyzed on a FACScan . Profile of intracellular staining of peripheral blood monocytes analyzed on a FACScan .

    BD Pharmingen™ Purified Mouse Anti-Human HLA-DM - Purified - Clone MaP.DM1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    克隆位点
    MaP-DM1
    亚型
    IgG1 kappa
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Denzin, Hammond, Cresswell: "HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules." in: The Journal of experimental medicine, Vol. 184, Issue 6, pp. 2153-65, (1997) (PubMed).

    Kropshofer, Hämmerling, Vogt: "How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?" in: Immunology today, Vol. 18, Issue 2, pp. 77-82, (1997) (PubMed).

    Denzin, Cresswell: "HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading." in: Cell, Vol. 82, Issue 1, pp. 155-65, (1995) (PubMed).

    Denzin, Robbins, Carboy-Newcomb, Cresswell: "Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells." in: Immunity, Vol. 1, Issue 7, pp. 595-606, (1995) (PubMed).

    Riberdy, Avva, Geuze, Cresswell: "Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines." in: The Journal of cell biology, Vol. 125, Issue 6, pp. 1225-37, (1994) (PubMed).

    Riberdy, Newcomb, Surman, Barbosa, Cresswell: "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides." in: Nature, Vol. 360, Issue 6403, pp. 474-7, (1992) (PubMed).

  • 抗原
    HLA-DM (MHC Class II HLA-DM (HLA-DM))
    别名
    HLA-DM
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