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- 抗原 See all CD43 (SPN) 抗体
- CD43 (SPN) (Sialophorin (SPN))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD43 antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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The S7 antibody reacts with the 115 kDa glycoform of CD43 (Ly-48, Leukosialin) which is expressed on IL-7-responsive pro-B cells, plasma cells, peritoneal and splenic CD5+ B cells (B-1 cells), granulocytes, monocytes, macrophages, platelets, natural killer cells, thymocytes, peripheral T cytotoxic/suppressor cells, and most T helper cells, but not resting conventional peripheral B cells. CD43 expression has also been detected on pluripotent hematopoietic stem cells and myeloid, lymphoid, and NK-cell progenitors in the bone marrow. Studies of CD43-deficient mice indicate that CD43 participates in the negative regulation of T-cell activation and adhesion. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.
BD Pharmingen™ Biotin Rat Anti-Mouse CD43 - Biotin - Clone S7 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Plasmacytoma MOPC-315
- 克隆位点
- S7
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product SPN Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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The functional paradox of CD43 in leukocyte recruitment: a study using CD43-deficient mice." in: The Journal of experimental medicine, Vol. 188, Issue 11, pp. 2181-6, (1999) (PubMed).
: "Negative regulation of T cell homing by CD43." in: Immunity, Vol. 8, Issue 3, pp. 373-81, (1998) (PubMed).
: "Regulation of in vitro and in vivo T cell activation by CD43." in: International immunology, Vol. 10, Issue 5, pp. 691-701, (1998) (PubMed).
: "A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors." in: The Journal of experimental medicine, Vol. 183, Issue 1, pp. 187-94, (1996) (PubMed).
: "Negative regulation of T-cell adhesion and activation by CD43." in: Nature, Vol. 377, Issue 6549, pp. 535-8, (1995) (PubMed).
: "Transplantable NK cell progenitors in murine bone marrow." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1653-63, (1995) (PubMed).
: "CD43 (S7) expression identifies peripheral B cell subsets." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 12, pp. 5503-15, (1995) (PubMed).
: "Characterization of the activation-associated isoform of CD43 on murine T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 8, pp. 3426-39, (1994) (PubMed).
: "Expression of CD43 on murine and human pluripotent hematopoietic stem cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 11, pp. 4978-87, (1994) (PubMed).
: "Generation of Ly-1 B cells from developmentally distinct precursors. Enrichment by stromal-cell culture or cell sorting." in: Annals of the New York Academy of Sciences, Vol. 651, pp. 99-111, (1992) (PubMed).
: "Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow." in: The Journal of experimental medicine, Vol. 173, Issue 5, pp. 1213-25, (1991) (PubMed).
: "Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 11, pp. 3751-7, (1988) (PubMed).
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The functional paradox of CD43 in leukocyte recruitment: a study using CD43-deficient mice." in: The Journal of experimental medicine, Vol. 188, Issue 11, pp. 2181-6, (1999) (PubMed).
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- 抗原
- CD43 (SPN) (Sialophorin (SPN))
- 别名
- CD43 (SPN 产品)
- 别名
- CD43 antibody, GALGP antibody, GPL115 antibody, LSN antibody, A630014B01Rik antibody, Cd43 antibody, Galgp antibody, Ly-48 antibody, Ly48 antibody, Lsn antibody, Lsn1 antibody, gpL115 antibody, sialophorin antibody, SPN antibody, Spn antibody
- 背景
- Synonyms: Ly-48, Leukosialin
- 途径
- Regulation of Leukocyte Mediated Immunity
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