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CXCR4 抗体

Name: CXCR4 抗体
SKU: ABIN2689046
Availability: OutOfStock

CXCR4 适用: 小鼠 WB, FACS 宿主: 大鼠 Monoclonal 2B11-CXCR4 unconjugated

(10 references)

产品编号 ABIN2689046

发货至: 中国

Datasheet as PDF

抗原 See all CXCR4 抗体

CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
适用
143

92

74

21

11

11

10

7

4

4

3

3

3

3

2

1

1

1

1
小鼠
宿主
124

21

12

4

1
大鼠
Compatible Secondaries
克隆类型
135

27
单克隆
标记
96

8

7

6

5

4

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
This CXCR4 antibody is un-conjugated
应用范围
118

57

44

36

29

25

25

25

18

11

8

6

4

4

3

3

2
Western Blotting (WB), Flow Cytometry (FACS)

品牌

BD Pharmingen™

产品特性

The 2B11/CXCR4 monoclonal antibody specifically reacts with mouse CD184, which is also known as CXC chemokine receptor, CXCR4. CXCR4 (previously known as Fusin and LESTR), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CXC chemokines, SDF-1/CXCL12. Mouse CXCR4 shows 91 % homology at amino acid level with human CXCR4. CXCR4 is widely expressed by hematopoietic and non-hematopoietic cell types including neutrophils, monocytes, T cells, B cells, CD34-positive progenitor cells, endothelial cells, neurons and astrocytes. Human CXCR4 is used by T-tropic HIV-1 as a co-receptor for viral entry. The mouse CXCR4 gene has been mapped to chromosome 1. Detection of CXCR4 expression on BALB/c thymocytes by purified 2B11/CXCR4. BALB/c thymocytes were stained with 0.5 μg/test of Purified Rat anti-Mouse CD184 using 3-step staining protocol outlined below and APC Rat anti-Mouse CD4 (Cat. No. 553051). The level of nonspecific staining was assessed by using Purified Rat IgG2b, κ Isotype Control(Cat. No. 553986). The quadrant markers for the bivariate dot plots were set based on the isotype control. Flow cytometry was performed on a FACScan™ Flow Cytometer .

BD Pharmingen™ Purified Rat Anti-Mouse CD184 (CXCR4) - Purified - Clone 2B11/CXCR4 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.1 mg

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

GST-NCXCR4 fusion protein

克隆位点

2B11-CXCR4

亚型

IgG2b kappa

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anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (C-Term) antibody
CXCR4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

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CXCR4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F8 unconjugated

anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody (PE)
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anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (AA 2-15), (Extracellular), (N-Term) antibody
CXCR4 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
De La Luz Sierra, Gasperini, McCormick, Zhu, Tosato: "Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells." in: Blood, Vol. 110, Issue 7, pp. 2276-85, (2007) (PubMed).

Schabath, Müller, Schubel, Kremmer, Lipp, Förster: "The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation." in: Journal of leukocyte biology, Vol. 66, Issue 6, pp. 996-1004, (2000) (PubMed).

Förster, Kremmer, Schubel, Breitfeld, Kleinschmidt, Nerl, Bernhardt, Lipp: "Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 3, pp. 1522-31, (1998) (PubMed).

Heesen, Berman, Benson, Gerard, Dorf: "Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 12, pp. 5455-60, (1997) (PubMed).

Bleul, Farzan, Choe, Parolin, Clark-Lewis, Sodroski, Springer: "The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry." in: Nature, Vol. 382, Issue 6594, pp. 829-33, (1997) (PubMed).

Bleul, Wu, Hoxie, Springer, Mackay: "The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 5, pp. 1925-30, (1997) (PubMed).

Hesselgesser, Halks-Miller, DelVecchio, Peiper, Hoxie, Kolson, Taub, Horuk: "CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons." in: Current biology : CB, Vol. 7, Issue 2, pp. 112-21, (1997) (PubMed).

Oberlin, Amara, Bachelerie, Bessia, Virelizier, Arenzana-Seisdedos, Schwartz, Heard, Clark-Lewis, Legler, Loetscher, Baggiolini, Moser: "The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1." in: Nature, Vol. 382, Issue 6594, pp. 833-5, (1997) (PubMed).

Feng, Broder, Kennedy, Berger: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, (1996) (PubMed).

Loetscher, Geiser, OReilly, Zwahlen, Baggiolini, Moser: "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes." in: The Journal of biological chemistry, Vol. 269, Issue 1, pp. 232-7, (1994) (PubMed).
抗原

CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

别名

CD184 CXCR4 (CXCR4 产品)

别名

CD184 antibody, D2S201E antibody, FB22 antibody, HM89 antibody, HSY3RR antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3R antibody, WHIM antibody, Cmkar4 antibody, PB-CKR antibody, PBSF/SDF-1 antibody, Sdf1r antibody, CXC-R4-B antibody, CXCR-4-B antibody, cd184 antibody, cxcr4 antibody, fb22 antibody, hm89 antibody, hsy3rr antibody, lap3 antibody, lcr1 antibody, lestr antibody, npy3r antibody, npyr antibody, npyrl antibody, npyy3r antibody, xcxcr4 antibody, CXC-R4 antibody, CXCR-4 antibody, d2s201e antibody, whim antibody, CXC-R4-A antibody, CXCR-4-A antibody, xCXCR4 antibody, CXCR4 antibody, cb403 antibody, zgc:109863 antibody, cb824 antibody, C-X-C motif chemokine receptor 4 antibody, chemokine (C-X-C motif) receptor 4 antibody, C-X-C motif chemokine receptor 4 S homeolog antibody, C-X-C chemokine receptor type 4 antibody, C-X-C motif chemokine receptor 4 L homeolog antibody, chemokine (C-X-C motif), receptor 4b antibody, chemokine (C-X-C motif) receptor 4a antibody, CXCR4 antibody, Cxcr4 antibody, cxcr4.S antibody, cxcr4 antibody, LOC100049444 antibody, cxcr4.L antibody, cxcr4b antibody, cxcr4a antibody

背景

Synonyms: CXCR4, C-X-C chemokine receptor type 4, Fusin, LESTR, PB-CKR, Sdf1r

途径

Regulation of Cell Size, CXCR4-mediated Signaling Events