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Cyclin E1 抗体 (AA 307-410)

CCNE1 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5F8C5 unconjugated
产品编号 ABIN2682980
发货至: 中国
  • 抗原 See all Cyclin E1 (CCNE1) 抗体
    Cyclin E1 (CCNE1)
    抗原表位
    • 27
    • 16
    • 16
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 307-410
    适用
    • 144
    • 36
    • 33
    • 3
    • 2
    • 2
    • 2
    人, 小鼠
    宿主
    • 121
    • 22
    • 1
    小鼠
    克隆类型
    • 115
    • 29
    单克隆
    标记
    • 79
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Cyclin E1 antibody is un-conjugated
    应用范围
    • 99
    • 48
    • 45
    • 41
    • 32
    • 28
    • 20
    • 13
    • 12
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human CCNE1 (AA: 307-410) expressed in E. coli.
    克隆位点
    5F8C5
    亚型
    IgG1
    Top Product
    Discover our top product CCNE1 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • 抗原
    Cyclin E1 (CCNE1)
    别名
    CCNE1 (CCNE1 产品)
    别名
    CCNE1 antibody, ccne antibody, cyclinE antibody, CCNE antibody, AW538188 antibody, CycE1 antibody, CYCLE antibody, Ccne antibody, cyce2 antibody, cycE3 antibody, cyce antibody, fa18e07 antibody, wu:fa18e07 antibody, cyclin E1 antibody, cyclin E1 L homeolog antibody, cyclin E1 S homeolog antibody, CCNE1 antibody, ccne1 antibody, Ccne1 antibody, ccne1.L antibody, ccne1.S antibody
    背景

    Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

    Aliases: CCNE

    分子量
    47 kDa
    基因ID
    898
    HGNC
    898
    途径
    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
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