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EZH2 抗体 (AA 1-370)

Name: EZH2 抗体 (AA 1-370)
SKU: ABIN2668958
Availability: OutOfStock

EZH2 适用: 人, 小鼠 IP, ChIP, ChIP-seq 宿主: 兔 Polyclonal unconjugated

ChIP

ChIP-seq

2 images

(9 references)

产品编号 ABIN2668958

发货至: 中国

Datasheet as PDF

抗原 See all EZH2 抗体

EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
抗原表位
16

15

8

4

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-370
适用
106

41

11

8

4

4

2

2

2

2

2

1

1

1

1
人, 小鼠
宿主
85

21

1
兔
Compatible Secondaries
克隆类型
75

32
多克隆
标记
63

6

4

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This EZH2 antibody is un-conjugated
应用范围
65

38

35

23

23

17

15

13

12

9

5

3

3

2

1

1
Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

纯化方法

None

免疫原

This EZH2 antibody was raised against a recombinant fusion protein corresponding to amino acids 1-370 of mouse EZH2.

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anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-250) antibody
EZH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

储存条件

-20 °C

储存方法

Antibodies in solution can be stored at -20 °C for 2 years.

有效期

6 months
LaFave, Béguelin, Koche, Teater, Spitzer, Chramiec, Papalexi, Keller, Hricik, Konstantinoff, Micol, Durham, Knutson, Campbell, Blum, Shi, Doud, Krivtsov, Chung, Khodos, de Stanchina, Ouerfelli et al.: "Loss of BAP1 function leads to EZH2-dependent transformation. ..." in: Nature medicine, Vol. 21, Issue 11, pp. 1344-9, (2015) (PubMed).

Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: "Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ..." in: Molecular cancer therapeutics, Vol. 13, Issue 4, pp. 842-54, (2014) (PubMed).

Inoue, Kitaura, Togami, Nishimura, Enomoto, Uchida, Kagiyama, Kawabata, Nakahara, Izawa, Oki, Maehara, Isobe, Tsuchiya, Harada, Harada, Ochiya, Aburatani, Kimura, Thol, Heuser, Levine, Abdel-Wahab et al.: "Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. ..." in: The Journal of clinical investigation, Vol. 123, Issue 11, pp. 4627-40, (2014) (PubMed).

Kumar, Duester: "Retinoic acid controls body axis extension by directly repressing Fgf8 transcription." in: Development (Cambridge, England), Vol. 141, Issue 15, pp. 2972-7, (2014) (PubMed).

Tong, He, Xie, Mochizuki, Liu, Mochizuki, Meng, Sun, Zhang, Guo, Hexner, Zhang: "Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5012-22, (2014) (PubMed).

Bender, Tang, Lindroth, Hovestadt, Jones, Kool, Zapatka, Northcott, Sturm, Wang, Radlwimmer, Højfeldt, Truffaux, Castel, Schubert, Ryzhova, Seker-Cin, Gronych, Johann, Stark, Meyer, Milde, Schuhmann et al.: "Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. ..." in: Cancer cell, Vol. 24, Issue 5, pp. 660-72, (2013) (PubMed).

Chng, Chang, Tan, Yang, Hong, Sng, Cheung: "A transcriptional repressor co-regulatory network governing androgen response in prostate cancers." in: The EMBO journal, Vol. 31, Issue 12, pp. 2810-23, (2012) (PubMed).

Abdel-Wahab, Adli, LaFave, Gao, Hricik, Shih, Pandey, Patel, Chung, Koche, Perna, Zhao, Taylor, Park, Carroll, Melnick, Nimer, Jaffe, Aifantis, Bernstein, Levine: "ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression." in: Cancer cell, Vol. 22, Issue 2, pp. 180-93, (2012) (PubMed).

Bredfeldt, Greathouse, Safe, Hung, Bedford, Walker: "Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 5, pp. 993-1006, (2010) (PubMed).
抗原

EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

别名

EZH2 (EZH2 产品)

分子量

96 kDa

基因ID

2146

途径

Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation