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- 抗原 See all TICAM1 抗体
- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TICAM1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 纯化方法
- The antibody was purified by affinity chromatography.
- 克隆位点
- 1H4B01
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product TICAM1 Primary Antibody
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anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 443-685) antibody
TICAM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 663-712) antibodyTICAM1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 263-526) antibodyTICAM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyTICAM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibodyTICAM1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 20-200) antibodyTICAM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (C-Term) antibodyTICAM1 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibodyVerified TICAM1 适用: 人 IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 120-420) antibodyTICAM1 适用: 人, 猴 WB 宿主: 小鼠 Monoclonal 1G7 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
- 别名
- TICAM-1 (TICAM1 产品)
- 别名
- IIAE6 antibody, MyD88-3 antibody, PRVTIRB antibody, TICAM-1 antibody, TRIF antibody, AW046014 antibody, AW547018 antibody, trif antibody, toll like receptor adaptor molecule 1 antibody, toll-like receptor adaptor molecule 1 antibody, TICAM1 antibody, Ticam1 antibody, ticam1 antibody
- 背景
- TICAM-1, also known as TRIF, is an intracellular adaptor protein utilized by TLR3 and TLR4. TLR3 recognizes double stranded viral RNA and induces TICAM-1 mediated type I interferon production. The N-terminal region of TICAM-1 recruits TBK1 and IKKi, which in turn phosphorylates the interferon regulatory transcription factor IRF3. The phosphorylated IRF3 is subsequently dimerized and translocates to the nucleus, resulting in transcriptional activation of the gene encoding IFN-β. Mice lacking in TICAM-1 expression are defective in the TLR3 mediated induction of proinflamatory cytokines, suggesting that TICAM-1 is crucial for TLR3 downstream signaling. TICAM-1 also mediates TLR4-induced signaling in the presence of the adaptor molecule TRAM. The C-terminal region of TICAM-1 recruits RIP1 and induces apoptosis through FADD/caspase cascade.
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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