Plexin B2 抗体
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- 抗原 See all Plexin B2 (PLXNB2) 抗体
- Plexin B2 (PLXNB2)
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适用
- 小鼠
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宿主
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Armenian Hamster
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克隆类型
- 单克隆
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标记
- This Plexin B2 antibody is un-conjugated
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应用范围
- Intracellular Flow Cytometry (ICFC)
- 纯化方法
- The antibody was purified by affinity chromatography.
- 克隆位点
- 3E7
- 亚型
- IgG
- Top Product
- Discover our top product PLXNB2 Primary Antibody
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anti-Plexin B2 (PLXNB2) (AA 1080-1200) antibody
PLXNB2 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Plexin B2 (PLXNB2) (AA 1458-1673) antibodyPLXNB2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Plexin B2 (PLXNB2) (AA 1506-1611) antibodyPLXNB2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- Plexin B2 (PLXNB2)
- 别名
- Plexin B2 (PLXNB2 产品)
- 别名
- PLXNB2 antibody, MM1 antibody, Nbla00445 antibody, PLEXB2 antibody, dJ402G11.3 antibody, 1110007H23Rik antibody, Debt antibody, mKIAA0315 antibody, plexin B2 antibody, plexin B2 S homeolog antibody, PLXNB2 antibody, plxnb2.S antibody, plxnb2 antibody, Plxnb2 antibody
- 背景
- Plexin B2 is a 240 kD transmembrane receptor belonging to the semaphorin receptor family, B subfamily. All the family members share an extracellular semaphorin domain and an intracellular plexin domain-containing tail that can mediate intracellular signaling. Distinct from the other subfamily members, Plexin B2 contains an intracellular domain with a PDZ motif (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zonula occludens-1 protein (zo-1)), which can relay extracellular signals to intracellular motifs. Similar to the other B family members, Plexin B2 was also originally found in the nervous system and was later reported on endocrine, reproductive, urinary, digestive, respiratory, and immune systems. In immune cells, Plexin B2 is highly expressed on macrophages, conventional dendritic cells (cDCs), and plasmacytoid dendritic cells (pDCs). It is also expressed on T cells and T-dependent germinal center B cells. Plexin B2 facilitates ligand induced cell guidance and migration in the nervous system, and induces cytoskeletal changes in overexpression assays through RhoGTPase. However, the function of Plexin B2 in the immune system is not conclusive. Plexin B2 has been reported to modulate upon activation of DCs by TLR ligands, TNF-α, and anti-CD40. It also functions as a negative regulator of Rac and Cdc42 and modulates cell motility in macrophages. Plexin B2 has been found to have several semaphorin ligands including Semaphorin-3E, Semaphorin-4A, Semaphorin-4C, and Semaphorin-4D.
- 途径
- Tube Formation
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