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- 抗原 See all NLRC4 抗体
- NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NLRC4 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 纯化方法
- The antibody was purified by affinity chromatography.
- 克隆位点
- 6H9B13
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product NLRC4 Primary Antibody
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anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibody
NLRC4 适用: 人, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 1-250) antibodyNLRC4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (pSer533) antibodyNLRC4 适用: 人, 小鼠 WB, ELISA, ICC 宿主: 大鼠 Monoclonal 4B7B7 unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) antibodyNLRC4 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibodyNLRC4 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 941-990) antibodyNLRC4 适用: 人, 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (N-Term) antibodyNLRC4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibodyNLRC4 适用: 人, 小鼠, 大鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 1-250) antibodyNLRC4 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, CARD Domain Containing 4 (NLRC4) (AA 531-630) antibodyNLRC4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
- 别名
- NLRC4 (NLRC4 产品)
- 别名
- CARD12 antibody, CLAN antibody, CLAN1 antibody, CLANA antibody, CLANB antibody, CLANC antibody, CLAND antibody, CLR2.1 antibody, IPAF antibody, 9530011P19Rik antibody, Card12 antibody, NLR family CARD domain containing 4 antibody, NLR family, CARD domain containing 4 antibody, NLRC4 antibody, Nlrc4 antibody
- 背景
- NLRC4 , also known as IPAF, is a member of the NOD-like receptor (NLR) family. The NLR proteins share a conserved DNA-binding NACHT domain, a caspase recruitment domain (CARD), and a leucine-rich repeat (LRR) domain responsible for pathogen pattern recognition. NLRC4 was found to play an important role in the innate immune response against bacterial infection. During Gram-negative bacteria infections, such as Shigella, Salmonella, Legionella, or Pseudomonas, NLRC4 detects and is activated by translocated bacterial flagellin or PrgJ-like rod proteins subsequently resulting in the assembly of the NLRC4 inflammasome. The activated inflammasome drives proteolytic activation of caspase-1, leading to the processing and secretion of the proinflamatory cytokines IL-1β and IL-18.
- 途径
- Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
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