电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

NLRC4 抗体

NLRC4 适用: 人 FACS 宿主: 小鼠 Monoclonal 6H9B13 unconjugated
产品编号 ABIN2665296
发货至: 中国
  • 抗原 See all NLRC4 抗体
    NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
    适用
    • 33
    • 15
    • 6
    • 2
    宿主
    • 21
    • 9
    • 3
    小鼠
    克隆类型
    • 22
    • 11
    单克隆
    标记
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NLRC4 antibody is un-conjugated
    应用范围
    • 22
    • 13
    • 9
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    6H9B13
    亚型
    IgG2a kappa
    Top Product
    Discover our top product NLRC4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))
    别名
    NLRC4 (NLRC4 产品)
    背景
    NLRC4 , also known as IPAF, is a member of the NOD-like receptor (NLR) family. The NLR proteins share a conserved DNA-binding NACHT domain, a caspase recruitment domain (CARD), and a leucine-rich repeat (LRR) domain responsible for pathogen pattern recognition. NLRC4 was found to play an important role in the innate immune response against bacterial infection. During Gram-negative bacteria infections, such as Shigella, Salmonella, Legionella, or Pseudomonas, NLRC4 detects and is activated by translocated bacterial flagellin or PrgJ-like rod proteins subsequently resulting in the assembly of the NLRC4 inflammasome. The activated inflammasome drives proteolytic activation of caspase-1, leading to the processing and secretion of the proinflamatory cytokines IL-1β and IL-18.
    途径
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
You are here:
客服