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CCR4 抗体

CCR4 适用: 人 ICFC 宿主: 小鼠 Monoclonal L291H4 unconjugated
产品编号 ABIN2664335
发货至: 中国
  • 抗原 See all CCR4 抗体
    CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))
    适用
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    宿主
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    小鼠
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    单克隆
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    This CCR4 antibody is un-conjugated
    应用范围
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    Intracellular Flow Cytometry (ICFC)
    交叉反应
    Cynomolgus
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    L291H4
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CCR4 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))
    别名
    CD194 (CCR4 产品)
    别名
    CC-CKR-4 antibody, CD194 antibody, CKR4 antibody, CMKBR4 antibody, ChemR13 antibody, HGCN:14099 antibody, K5-5 antibody, Ccr4 antibody, C-C CKR-4 antibody, CHEMR1 antibody, Cmkbr4 antibody, LESTR antibody, Sdf1r antibody, C-C motif chemokine receptor 4 antibody, chemokine (C-C motif) receptor 4 antibody, CCR4 antibody, Ccr4 antibody
    背景
    CD194, also known as CCR4, is a CC chemokine receptor. It binds CCL17 and CCL22 and is expressed on a subset of T and B cells, basophils, monocytes, and NK cells. Human Th2 cells are characterized by the expression of CCR4 and CCR8, and these receptors are regulated differently during Th2 development. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4- Tregs require CD3-mediated activation to acquire a regulatory activity. Depletion of CCR4+ T cells leads to Th1-type polarization of CD4+ T cells and augmentation of CD8+ T cell responses to tumor antigens. CCR4 and its ligands are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
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