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LAG3 抗体 (Biotin)

LAG3 适用: 小鼠 IHC, FACS, IF 宿主: 大鼠 Monoclonal C9B7W Biotin
产品编号 ABIN2660995
发货至: 中国
  • 抗原 See all LAG3 抗体
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    适用
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    小鼠
    宿主
    • 52
    • 34
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    大鼠
    克隆类型
    • 53
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    单克隆
    标记
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    This LAG3 antibody is conjugated to Biotin
    应用范围
    • 68
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    Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
    纯化方法
    The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
    克隆位点
    C9B7W
    亚型
    IgG1 kappa
    Top Product
    Discover our top product LAG3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    别名
    CD223 (LAG3 产品)
    别名
    CD223 antibody, LAG-3 antibody, Ly66 antibody, lymphocyte activating 3 antibody, lymphocyte-activation gene 3 antibody, LAG3 antibody, Lag3 antibody
    背景
    CD223, also known as LAG-3, is 70 kD type I transmembrane glycoprotein within the Ig superfamily. It is the gene product of lymphocyte activation gene-3 (Lag3) with structural similarity to CD4. CD223 is expressed on activated T cells and NK cells, as well as T regulatory cells. CD223, like CD4, binds MHC class II molecules, but with higher affinity than CD4. In association with the CD3 complex, CD223 has been shown as a negative regulatory molecule to inhibit TCR-mediated signaling and regulate homeostatic T cell expansion. In contrast to inhibition, CD223 has an activation function to promote immune responses by inducing MHC class II signaling in antigen presenting cells.
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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