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LRRC32 抗体 (APC)

LRRC32 适用: 人 BCA 宿主: 小鼠 Monoclonal 7B11 APC
产品编号 ABIN2658317
发货至: 中国
  • 抗原 See all LRRC32 抗体
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    适用
    • 27
    • 10
    • 9
    • 1
    宿主
    • 20
    • 13
    • 1
    • 1
    小鼠
    克隆类型
    • 21
    • 14
    单克隆
    标记
    • 19
    • 7
    • 4
    • 2
    • 2
    • 1
    This LRRC32 antibody is conjugated to APC
    应用范围
    • 17
    • 16
    • 14
    • 6
    • 4
    • 3
    • 2
    • 1
    Biochemical Assay (BCA)
    纯化方法
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    克隆位点
    7B11
    亚型
    IgG2b kappa
    Top Product
    Discover our top product LRRC32 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from prolonged exposure to light. Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    别名
    GARP (LRRC32 产品)
    别名
    D11S833E antibody, GARP antibody, AI426318 antibody, D11S833Eh antibody, D7H11S833E antibody, EG434215 antibody, Garp antibody, leucine rich repeat containing 32 antibody, LRRC32 antibody, Lrrc32 antibody
    背景
    Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs (CD4+, CD25+, FoxP3+ cells) and serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1, an autosomal recessive disease characterized by profound congenital sensorineural deafness, vestibular dysfunction, and progressive visual loss. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.
    途径
    Activated T Cell Proliferation
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