The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
lib antibody, GPV antibody, PLGPV antibody, CD42d antibody, glycoprotein V platelet L homeolog antibody, glycoprotein V platelet antibody, glycoprotein 5 (platelet) antibody, glycoprotein V (platelet) antibody, gp5.L antibody, GP5 antibody, Gp5 antibody
背景
CD42d is an 83 kD surface glycoprotein that non-covalently associates with GPIb and GPIX to form a receptor complex for von Willebrand factor on megakaryocytes and resting platelets. Binding sites for von Willebrand factor and thrombin have been localized to the GPIba chain of the GPI-b-V-IX complex. Platelet activation with thrombin cleaves the GPI-b-V-IX complex to release a 69 kD soluble fragment. Presence of the GPI-b-V-IX complex is important in Bernard-Soulier syndrome, a rare bleeding disorder.