IKZF3 抗体 (Alexa Fluor 647)
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- 抗原 See all IKZF3 抗体
- IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IKZF3 antibody is conjugated to Alexa Fluor 647
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应用范围
- Flow Cytometry (FACS)
- 无交叉反应
- 小鼠
- 纯化方法
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- 克隆位点
- 8B2
- 亚型
- IgG1 kappa, IgG
- Top Product
- Discover our top product IKZF3 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Protect from prolonged exposure to light. Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C
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- 抗原
- IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))
- 别名
- Aiolos (IKZF3 产品)
- 别名
- AIO antibody, AIOLOS antibody, ZNFN1A3 antibody, aio antibody, aiolos antibody, znfn1a3 antibody, IKZF3 antibody, 5830411O07Rik antibody, Aiolos antibody, Zfpn1a3 antibody, Znfn1a3 antibody, IKAROS family zinc finger 3 antibody, IKAROS family zinc finger 3 L homeolog antibody, IKZF3 antibody, ikzf3.L antibody, Ikzf3 antibody
- 背景
- Aiolos, an Ikaros family member, is also known as Izkf3. It has a molecular weight of 58 kD and shows 70 % homology to the Ikaros isoform, Ik-1, particularly in the DNA binding and C-terminal domains. Aiolos can form a heteromer with Ikaros or exist as a homodimer. The homomeric complex is a potent transcriptional activator. Unlike Ikaros, Aiolos is expressed in late fetal thymus and adult lymphoid organs. Among the adult hematopoietic progenitors, Aiolos is expressed at low levels in mulitpotent but not in pluripotent stem cells. When these multipotent progenitors become more restricted to T and B lymphoid pathways there is an upregulation in Aiolos expression. The highest expression of Aiolos is detected in the spleen (especially in B-cells) followed by thymus and bone marrow, and cannot be detected in the non-lymphoid organs. Aiolos plays an important role in lymphocyte proliferation and differentiation.
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