BAX 抗体 (Isoform beta)
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- 抗原 See all BAX 抗体
- BAX (BCL2-Associated X Protein (BAX))
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抗原表位
- AA 172-199, Isoform beta
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适用
- 小鼠
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宿主
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绵羊
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克隆类型
- 多克隆
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标记
- This BAX antibody is un-conjugated
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应用范围
- Immunoprecipitation (IP)
- 特异性
- This antibody reacts to Bax-beta.
- 纯化方法
- Purified
- 免疫原
- Synthetic peptide corresponding to amino acids 172 to 199 of the Bax beta protein
- 亚型
- IgG
- Top Product
- Discover our top product BAX Primary Antibody
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- 应用备注
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Immunoprecipitation. Will NOT detect denatured protein by Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- Phosphate buffered saline with 0.08 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- 抗原
- BAX (BCL2-Associated X Protein (BAX))
- 别名
- Bax (BAX 产品)
- 背景
- Bax-beta is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax-beta protein before a stop codon is encountered during translation. The Bax-beta protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax-beta mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax-alpha in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax-beta mRNA was very abundant in brain and duodenum with almost no Bax-alpha mRNA detected in these tissues (Oltvai et al., 1993).Synonyms: Apoptosis regulator BAX, BCL2-associated X protein, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
- 基因ID
- 12028
- NCBI登录号
- NP_031553
- UniProt
- Q07813
- 途径
- p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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