HCV E2 抗体 (AA 384-665)
HCV E2
适用: Hepatitis C Virus (HCV)
WB, IF, EIA
宿主: 山羊
Polyclonal
unconjugated
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- 抗原 See all HCV E2 抗体
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
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抗原表位
- AA 384-665
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适用
- Hepatitis C Virus (HCV)
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This HCV E2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- 纯化方法
- Sodium Sulfate Precipitation and Ion-Exchange Chromatography.
- 免疫原
- Recombinant E2 (genotype 1a)
- Top Product
- Discover our top product HCV E2 Primary Antibody
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- 应用备注
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Conjugation-ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 4-5 mg/mL (OD280nm, E0.1% = 1.4)
- 缓冲液
- 0.01 M PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and no stabilizing proteins.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
- 别名
- HCV Envelope Glycoprotein E2 (HCV E2 产品)
- 物质类
- Viral Protein
- 背景
- Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.Synonyms: Hepatitis C Virus NS1, gp68, gp70
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