Retinoblastoma 1 抗体 (AA 393-572, AA 622-645)
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- 抗原 See all Retinoblastoma 1 (RB1) 抗体
- Retinoblastoma 1 (RB1)
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抗原表位
- AA 393-572, AA 622-645
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适用
- 人, 小鼠, 大鼠, 小鸡, Mink
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Retinoblastoma 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 特异性
- Recognizes Retinoblastoma (Rb).
- 产品特性
- Synonyms: Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
- 纯化方法
- Purified
- 免疫原
- Recombinant protein corresponding to amino acids 393-572 of the Human Retinoblastomasequence. Remarks: The epitope is contained within amino acids 622-645 of Humanretinoblastoma.
- 克隆位点
- XZ91
- 亚型
- IgG1
- Top Product
- Discover our top product RB1 Primary Antibody
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- 应用备注
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Western Blot. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.08 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
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Store the antibody (in aliquots) at -20 °C. Can be shipped at 2-8 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. - 有效期
- 12 months
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- 抗原
- Retinoblastoma 1 (RB1)
- 别名
- Retinoblastoma-Associated Protein / RB1 (RB1 产品)
- 别名
- OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody
- 背景
- Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
- 基因ID
- 5925
- UniProt
- P06400
- 途径
- Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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