Valproic Acid 抗体
EIA
宿主: 小鼠
Monoclonal
801
unconjugated
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- 抗原 See all Valproic Acid products
- Valproic Acid
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Valproic Acid antibody is un-conjugated
- 应用范围
- Enzyme Immunoassay (EIA)
- 纯化方法
- Protein G chromatography
- 免疫原
- Valproic acid conjugated to KLH
- 克隆位点
- 801
- 亚型
- IgG1
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- 应用备注
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May be used in immunoassays to detect and quantitate valproic acid.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.2mg/mL (OD280nm)
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
- 储存方法
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Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- Valproic Acid
- Abstract
- Valproic Acid 产品
- 物质类
- Chemical
- 背景
- Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
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