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AHNAK 抗体 (N-Term)

AHNAK 适用: 人, 小鼠 WB, IP, IHC (fro), IF 宿主: 小鼠 Monoclonal EM-09 unconjugated
产品编号 ABIN263928
发货至: 中国
  • 抗原 See all AHNAK 抗体
    AHNAK (AHNAK Nucleoprotein (AHNAK))
    抗原表位
    • 15
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 46
    • 10
    • 1
    人, 小鼠
    宿主
    • 33
    • 11
    • 2
    小鼠
    克隆类型
    • 38
    • 8
    单克隆
    标记
    • 21
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AHNAK antibody is un-conjugated
    应用范围
    • 16
    • 14
    • 13
    • 13
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    特异性
    The antibody reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.
    交叉反应 (详细)
    Species reactivity (tested):Human, Mouse.
    产品特性
    Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK
    纯化方法
    Protein A Affinity Chromatography
    免疫原
    Bacterially expressed fragment of N-terminal domain of human AHNAK1
    克隆位点
    EM-09
    亚型
    IgG1
    Top Product
    Discover our top product AHNAK Primary Antibody
  • 应用备注
    Immunohistochemistry on frozen sections. Western blot (Positive control: HeLa human cervix carcinoma cell line). Immunocytochemistry (Permeabilization is required, positive control: HeLa human cervixcarcinoma cell line). Immunoprecipitation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH ~7.4, 15 mM Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 to -80 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    AHNAK (AHNAK Nucleoprotein (AHNAK))
    Abstract
    AHNAK 产品
    别名
    AHNAKRS antibody, 1110004P15Rik antibody, 2310047C17Rik antibody, AA589382 antibody, AV091586 antibody, DY6 antibody, AHNAK 1 antibody, RGD1308572 antibody, UV118 antibody, AHNAK antibody, wu:fb05a01 antibody, wu:fu74f12 antibody, LOC733715 antibody, AHNAK nucleoprotein antibody, AHNAK nucleoprotein (desmoyokin) antibody, AHNAK nucleoprotein pseudogene antibody, AHNAK antibody, Ahnak antibody, ahnak antibody, LOC748622 antibody
    背景
    AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear, it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK
    基因ID
    79026
    UniProt
    Q09666
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