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FKBP5 抗体 (HRP)

FKBP5 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal Hi51B HRP
产品编号 ABIN2486514
发货至: 中国
  • 抗原 See all FKBP5 抗体
    FKBP5 (FK506 Binding Protein 5 (FKBP5))
    适用
    • 57
    • 21
    • 18
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 46
    • 17
    • 1
    小鼠
    克隆类型
    • 41
    • 23
    单克隆
    标记
    • 33
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FKBP5 antibody is conjugated to HRP
    应用范围
    • 43
    • 17
    • 17
    • 13
    • 12
    • 8
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Detects ~51 kDa.
    交叉反应
    犬, Hamster, 人, 小鼠, 兔, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Synthetic peptide corresponding to the residues of human FKBP51
    克隆位点
    Hi51B
    亚型
    IgG1
    Top Product
    Discover our top product FKBP5 Primary Antibody
  • 应用备注
    • WB (1:2000)
    • ICC/IF (1:1000)
    • optimal dilutions for assays should be determined by the user.
    说明

    A 1:2000 dilution was sufficient for detection of FKBP51 in ~50 μg total protein using WB analysis.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    FKBP5 (FK506 Binding Protein 5 (FKBP5))
    别名
    FKBP51 (FKBP5 产品)
    别名
    FKBP5 antibody, FKBP-5 antibody, AIG6 antibody, FKBP51 antibody, FKBP54 antibody, P54 antibody, PPIase antibody, Ptg-10 antibody, D17Ertd592e antibody, Dit1 antibody, si:zc263a23.8 antibody, wu:fc31g11 antibody, wu:fl87b03 antibody, zgc:64082 antibody, FK506 binding protein 5 antibody, FKBP5 antibody, fkbp5 antibody, Fkbp5 antibody
    背景
    HSP90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of HSP90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an HSP90 binding site. Among the TPR cochaperones of HSP90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the HSP90 (4). Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different HSP90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).
    基因ID
    2289
    NCBI登录号
    NP_001139247
    UniProt
    Q13451
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