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- 抗原 See all HSPB2 抗体
- HSPB2 (Heat Shock 27kDa Protein 2 (HSPB2))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HSPB2 antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Detects ~27 kDa.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Protein A Purified
- 免疫原
- Synthetic peptide
- Top Product
- Discover our top product HSPB2 Primary Antibody
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anti-Heat Shock 27kDa Protein 2 (HSPB2) (AA 12-170) antibody
HSPB2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) (AA 1-182) antibodyHSPB2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4B9E2 unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) (AA 12-182) antibodyHSPB2 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) (AA 1-182) antibodyHSPB2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) (Internal Region) antibodyHSPB2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) (AA 1-182) antibodyHSPB2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) (AA 1-182) antibodyHSPB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) antibodyHSPB2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heat Shock 27kDa Protein 2 (HSPB2) antibody (HRP)HSPB2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal HRP
anti-Heat Shock 27kDa Protein 2 (HSPB2) antibody (PE)HSPB2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal PE
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- 应用备注
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- 说明
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1 μg/ml of ABIN2486040 was sufficient for detection of MKBP in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, 50 % glycerol, 0.02 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Conjugated antibodies should be stored at 4°C
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- 抗原
- HSPB2 (Heat Shock 27kDa Protein 2 (HSPB2))
- 别名
- HSPB2 (HSPB2 产品)
- 别名
- zgc:112532 antibody, HSP27 antibody, Hs.78846 antibody, LOH11CR1K antibody, MKBP antibody, 27kDa antibody, 2810021G24Rik antibody, heat shock protein family B (small) member 2 antibody, heat shock protein, alpha-crystallin-related, b2 antibody, heat shock protein 2 antibody, HSPB2 antibody, hspb2 antibody, Hspb2 antibody
- 背景
- HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30 % sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSPs, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP's localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic (1). HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis (4).
- 基因ID
- 3316
- NCBI登录号
- NP_001532
- UniProt
- Q16082
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