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DLG4 抗体 (FITC)

DLG4 适用: 大鼠 WB, IHC, IF, ICC, AA 宿主: 小鼠 Monoclonal 6G6 FITC
产品编号 ABIN2484816
发货至: 中国
  • 抗原 See all DLG4 抗体
    DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))
    适用
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    大鼠
    宿主
    • 102
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    小鼠
    克隆类型
    • 96
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    单克隆
    标记
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    This DLG4 antibody is conjugated to FITC
    应用范围
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    特异性
    Detects ~100 kDa. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at ~75 kDa and 50 kDa in rat and mouse samples.
    交叉反应
    Cow, 人, 小鼠, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Recombinant rat PSD-95
    克隆位点
    6G6
    亚型
    IgG2a
    Top Product
    Discover our top product DLG4 Primary Antibody
  • 应用备注
    • WB (1:250)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    说明

    1 μg/ml was sufficient for detection of PSD-95 on 20 μg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))
    别名
    PSD95 (DLG4 产品)
    别名
    11 antibody, CG1725 antibody, CG1730 antibody, CPD antibody, DLG antibody, DLG-A antibody, Discs-large antibody, Dlg antibody, Dlg-A antibody, Dlg1 antibody, DlgA antibody, Dmel\\CG1725 antibody, Drodlg antibody, PSD95 antibody, SAP97 antibody, anon-EST:Posey93 antibody, anon-WO03040301.258 antibody, anon-WO03040301.260 antibody, anon-WO03040301.268 antibody, d. lg.-1 antibody, dlg antibody, dlg-1 antibody, dlg-A antibody, dlgA antibody, dlgS97 antibody, l(1)10Bf antibody, l(1)G0276 antibody, l(1)G0342 antibody, l(1)G0456 antibody, l(1)G19 antibody, l(1)L11 antibody, l(1)bwn antibody, l(1)d.lg-1 antibody, l(1)d.lg.-1 antibody, l(1)discs large antibody, l(1)dlg antibody, l(1)dlg-1 antibody, l(1)dlg1 antibody, l(1)l.pr.-2 antibody, l(1)lpr-2 antibody, misb antibody, dlgh4 antibody, psd95 antibody, sap90 antibody, sap-90 antibody, LLGL1 antibody, Dlgh4 antibody, PSD-95 antibody, SAP90 antibody, SAP90A antibody, Sap90 antibody, SAP-90 antibody, DLG4 antibody, discs large 1 antibody, discs, large homolog 4 antibody, discs large MAGUK scaffold protein 4 antibody, discs, large homolog 4b (Drosophila) antibody, discs, large homolog 4 (Drosophila) antibody, dlg1 antibody, dlg4 antibody, DLG4 antibody, dlg4b antibody, Dlg4 antibody
    背景
    Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).
    基因ID
    29495
    NCBI登录号
    NP_062567
    UniProt
    P31016
    途径
    Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
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