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SHANK2 抗体 (AA 84-309) (APC)

SHANK2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal N23b-49 (Formerly S23b-49) APC
产品编号 ABIN2484048
发货至: 中国
  • 抗原 See all SHANK2 抗体
    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
    抗原表位
    • 27
    • 15
    • 10
    • 8
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 84-309
    适用
    • 45
    • 33
    • 33
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 47
    • 31
    • 1
    小鼠
    克隆类型
    • 49
    • 30
    单克隆
    标记
    • 27
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHANK2 antibody is conjugated to APC
    应用范围
    • 72
    • 34
    • 29
    • 25
    • 20
    • 20
    • 16
    • 13
    • 13
    • 10
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
    特异性
    Detects ~160 kDa. Recognizes Shank1, 2 and 3.
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Fusion protein amino acids 84-309 of rat Shank2
    克隆位点
    N23b-49 (Formerly S23b-49)
    亚型
    IgG1
    Top Product
    Discover our top product SHANK2 Primary Antibody
  • 应用备注
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    说明

    1 μg/ml of ABIN2484048 was sufficient for detection of Shank1-4 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
    别名
    SHANK (SHANK2 产品)
    别名
    AUTS17 antibody, CORTBP1 antibody, CTTNBP1 antibody, ProSAP1 antibody, SHANK antibody, SPANK-3 antibody, mKIAA1022 antibody, auts17 antibody, cortbp1 antibody, cttnbp1 antibody, prosap1 antibody, spank-3 antibody, shank2 antibody, MGC122482 antibody, CortBP1 antibody, Spank-3 antibody, SHANK2 antibody, SH3 and multiple ankyrin repeat domains 2 antibody, SH3 and multiple ankyrin repeat domains 2 L homeolog antibody, SH3 and multiple ankyrin repeat domains protein 2 antibody, SHANK2 antibody, Shank2 antibody, shank2.L antibody, shank2 antibody, LOC100438523 antibody
    背景
    Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina (2). Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease (3).
    基因ID
    171093
    UniProt
    Q9QX74
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