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Calnexin 抗体 (C-Term) (Biotin)

CANX 适用: 犬 WB, IHC, IF, IP, FACS, ICC 宿主: 兔 Polyclonal Biotin
产品编号 ABIN2481640
发货至: 中国
  • 抗原 See all Calnexin (CANX) 抗体
    Calnexin (CANX)
    抗原表位
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    C-Term
    适用
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    宿主
    • 120
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    克隆类型
    • 120
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    多克隆
    标记
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    This Calnexin antibody is conjugated to Biotin
    应用范围
    • 121
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    特异性
    Detects the C-terminal domain of Calnexin ~90 kDa. Weak detection in Chicken, Drosophila, and Xenopus tissues.
    交叉反应
    小鸡, Cow, 犬, Drosophila melanogaster, 豚鼠, Hamster, 人, 猴, 小鼠, Pig, Quail, 兔, 大鼠, 绵羊, 非洲爪蟾
    纯化方法
    Protein A Purified
    免疫原
    Dog Calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
    Top Product
    Discover our top product CANX Primary Antibody
  • 应用备注
    • WB (1:2000)
    • ICC/IF (1:100)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    说明

    A 1:2000 dilution of ABIN2481640 was sufficient for detection of Calnexin in 10 μg of HeLa cell lysate by ECL immunoblot analysis.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.2, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    Calnexin (CANX)
    别名
    Calnexin (CANX 产品)
    别名
    CNX antibody, IP90 antibody, P90 antibody, 1110069N15Rik antibody, AI988026 antibody, Cnx antibody, D11Ertd153e antibody, canx antibody, clgn antibody, clnx antibody, cnx antibody, PP90 antibody, zgc:63524 antibody, wu:fe06b12 antibody, CANX antibody, calnexin antibody, CalNeXin antibody, calnexin L homeolog antibody, CANX antibody, Canx antibody, cnx-1 antibody, canx.L antibody, canx antibody, LOC100283947 antibody
    背景
    Calnexin, an abundant ~90 kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50 kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3). Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multi-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).
    基因ID
    403908
    NCBI登录号
    NP_001003232
    UniProt
    P24643
    途径
    MAPK Pathway, Thyroid Hormone Synthesis
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