Corticosteroid 11-beta-dehydrogenase, isozyme 2 antibody can be used for the detection of Corticosteroid 11-beta-dehydrogenase, isozyme 2 by Western Blot.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
Phosphate-Buffered Saline. No preservatives added.
储存液
Without preservative
注意事项
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
储存条件
4 °C/-20 °C
储存方法
HSD11B2 antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.
FUNCTION: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
DISEASE: Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.