PATZ1 antibody can be used for detection of PATZ1 by ELISA at 1:1562500. PATZ1 antibody can be used for detection of PATZ1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
限制
仅限研究用
状态
Lyophilized
溶解方式
Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
浓度
1 mg/mL
缓冲液
Antibody is lyophilized in PBS buffer with 2 % sucrose.
注意事项
As with any antibody avoid repeat freeze-thaw cycles.
储存条件
4 °C/-20 °C
储存方法
For short periods of storage (days) store at 4 °C. For longer periods of storage, store PATZ1 antibody at -20 °C.
ZNF278 antibody, MAZR antibody, PATZ antibody, RIAZ antibody, ZBTB19 antibody, ZSG antibody, dJ400N23 antibody, 8430401L15Rik antibody, AI447519 antibody, Mazr antibody, Patz antibody, Zfp278 antibody, Znf278 antibody, POZ/BTB and AT hook containing zinc finger 1 antibody, POZ/BTB and AT hook containing zinc finger 1 S homeolog antibody, POZ (BTB) and AT hook containing zinc finger 1 antibody, POZ-, AT hook-, and zinc finger-containing protein 1 antibody, PATZ1 antibody, patz1.S antibody, Patz1 antibody, LOC100153931 antibody
背景
PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1,22) (p36.1,q12).The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1,22) (p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.