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SUMO2/3 抗体 (full length)

SUMO2/3 适用: 人, 小鼠, 大鼠 WB, IF, ELISA, IHC (fro) 宿主: 大鼠 Monoclonal 3H12 unconjugated
产品编号 ABIN2452139
发货至: 中国
  • 抗原 See all SUMO2/3 products
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    抗原表位
    • 16
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length
    适用
    • 48
    • 13
    • 13
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 38
    • 10
    大鼠
    克隆类型
    • 30
    • 18
    单克隆
    标记
    • 14
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SUMO2/3 antibody is un-conjugated
    应用范围
    • 41
    • 24
    • 14
    • 14
    • 14
    • 13
    • 10
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Specific to SUMO2 and SUMO3 of human, simian, mouse, hamster and rat. Does not react with SUMO1. This antibody recognizes both SUMO2 and SUMO3, but not SUMO1.
    交叉反应 (详细)
    Not tested for other species
    纯化方法
    The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.
    过滤
    Sterile filtered
    免疫原
    Recombinant GST-fused human SUMO3 (full length)
    克隆位点
    3H12
    亚型
    IgG2a kappa
  • 应用备注
    1. Western blotting: 1/1,000
    2. Immunocytochemistry/Immunofluorescence staining: 1/100~1/500
    3. Immunohistochemistry,frozen section: 1/100~1/500
    4. ELISA (Assay dependent concentration)
    Other applications have not been tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS (x1), 50 % glycerol. Azide and carrier free.
    储存液
    Azide free
    储存条件
    -20 °C
    储存方法
    Upon arrival centrifuge briefly and store at -20 C.
  • Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

  • 抗原
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    别名
    SUMO2/3 (SUMO2/3 产品)
    别名
    SUMO2 antibody, small ubiquitin-like modifier 2 antibody, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antibody, small ubiquitin-related modifier 2 antibody, SUMO2 antibody, LOC711990 antibody, LOC714892 antibody
    背景
    SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 and 3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO2/3 forms poly-(SUMO) chains, is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.
    分子量
    10,871 Da with 95 AA, 11,637 Da with 103 AA
    UniProt
    P61956, P55854
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