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SUMO1 抗体 (full length)

SUMO1 适用: 人 WB, IF, ELISA, IHC (p) 宿主: 大鼠 Monoclonal 4D12 unconjugated
产品编号 ABIN2452138
发货至: 中国
  • 抗原 See all SUMO1 抗体
    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
    抗原表位
    • 15
    • 15
    • 11
    • 8
    • 8
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length
    适用
    • 94
    • 78
    • 73
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 99
    • 31
    • 2
    • 1
    • 1
    大鼠
    克隆类型
    • 91
    • 44
    单克隆
    标记
    • 68
    • 10
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SUMO1 antibody is un-conjugated
    应用范围
    • 108
    • 46
    • 45
    • 37
    • 33
    • 27
    • 26
    • 23
    • 16
    • 9
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    Specific to human, simian, mouse and rat SUMO1.
    交叉反应 (详细)
    Not tested for other species
    纯化方法
    The antibody was produced in serum-free medium and purified by proprietary chromatography procedures under mild conditions.
    过滤
    Sterile filtered
    免疫原
    Recombinant GST-fused human SUMO1 (full length)
    克隆位点
    4D12
    亚型
    IgG2a kappa
    Top Product
    Discover our top product SUMO1 Primary Antibody
  • 应用备注
    1. Western blotting: 1/1,000
    2. Immunofluorescence staining: 1/100 dilution
    3. Immunohistochemistry,Frozen section: 1/100 dilution
    4. ELISA (assay dependent)
    Other applications have not been tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS (x1), 50 % glycerol. Azide and carrier free.
    储存液
    Azide free
    储存条件
    -20 °C
    储存方法
    Upon arrival centrifuge briefly and store at -20 C.
  • Ulrich: "The fast-growing business of SUMO chains." in: Molecular cell, Vol. 32, Issue 3, pp. 301-5, (2008) (PubMed).

    Saitoh, Uchimura, Tachibana, Sugahara, Saitoh, Nakao: "In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies." in: Experimental cell research, Vol. 312, Issue 8, pp. 1418-30, (2006) (PubMed).

    Uchimura, Ichimura, Uwada, Tachibana, Sugahara, Nakao, Saitoh: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).

    Cheng, Bawa, Lee, Gong, Yeh: "Role of desumoylation in the development of prostate cancer." in: Neoplasia (New York, N.Y.), Vol. 8, Issue 8, pp. 667-76, (2006) (PubMed).

  • 抗原
    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
    别名
    SUMO1 (SUMO1 产品)
    背景
    SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. Unlike ubiquitination, which targets proteins for degradation, SUMO modification plays a critical role in a number of cellular functions including nucleocytoplasmic transport, gene expression, cell cycle and formation of subnuclear structures such as promyelocytic leukemia (PML) bodies. There are three confirmed SUMO isoforms in human, SUMO1, SUMO2 and SUMO3. SUMO2 /3 show a high degree of similarity to each other and are distinct from SUMO1. Individual SUMO family members are all targeted to different proteins with diverse biological functions. SUMO-1 is conjugated to RanGAP, PML, p53 and IkappaB-alpha to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability. SUMO1 is encoded as a 101 aa protein and first Met and C-terminal 4 aa are removed from the preprotein.
    UniProt
    P63165
    途径
    M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway
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