2900068C24Rik antibody, Ddxbp1 antibody, GBP antibody, DDXBP1 antibody, GU/RH-II antibody, ZMIZ3 antibody, ddxbp1 antibody, gbp antibody, pias antibody, pias1-A antibody, xPAIS1 antibody, xPIAS1 antibody, zmiz3 antibody, protein inhibitor of activated STAT 1 antibody, protein inhibitor of activated STAT, 1 antibody, protein inhibitor of activated STAT, 1a antibody, protein inhibitor of activated STAT 1 L homeolog antibody, PIAS1 antibody, Pias1 antibody, pias1a antibody, pias1.L antibody
背景
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.