电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

ATR 抗体 (Internal Region)

ATR 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN233834
发货至: 中国
  • 抗原 See all ATR 抗体
    ATR (ATR serine/threonine kinase (ATR))
    抗原表位
    • 11
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 45
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 39
    • 5
    • 2
    克隆类型
    • 42
    • 4
    多克隆
    标记
    • 30
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATR antibody is un-conjugated
    应用范围
    • 26
    • 21
    • 20
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    交叉反应
    小鼠, 大鼠, 猴, 犬, 鱼, 非洲爪蟾
    产品特性
    Concentration Definition: by UV absorbance at 280 nm
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an of human ATR protein.
    亚型
    IgG
    Top Product
    Discover our top product ATR Primary Antibody
  • 应用备注
    This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 301 kDa in size corresponding to ATR by western blotting in the appropriate cell lysate or extract.  Lysates from HeLa, U2OS, RAW264.7 or HEK293 cells are suggested for western blotting.  ATR is ubiquitously expressed, with highest expression levels in the testes.  Note that isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.28 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    ATR (ATR serine/threonine kinase (ATR))
    别名
    ATR (ATR 产品)
    别名
    FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody
    背景
    Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidyl-inositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle.  ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor.  ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4).  ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis.  ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types.  ATR is recruited to chromatin during S-phase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
    Synonyms: ACTR antibody, AIB1 antibody, amplified in breast cancer 1 antibody, Ataxia Telangiecasia and Rad3 Related antibody, CAGH16 antibody, CBP interacting protein antibody, CTG26 antibody, FRAP Related Protein 1 antibod
    基因ID
    545, 157266317
    UniProt
    Q13535
    途径
    Positive Regulation of Response to DNA Damage Stimulus
You are here:
客服