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PPP1R13B 抗体 (Internal Region)

PPP1R13B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN233830
发货至: 中国
  • 抗原 See all PPP1R13B 抗体
    PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
    抗原表位
    • 15
    • 7
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
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    • 1
    Internal Region
    适用
    • 51
    • 12
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    • 2
    • 2
    • 2
    • 1
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    • 1
    • 1
    • 1
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    宿主
    • 50
    • 1
    克隆类型
    • 50
    • 1
    多克隆
    标记
    • 16
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    This PPP1R13B antibody is un-conjugated
    应用范围
    • 37
    • 24
    • 13
    • 13
    • 3
    • 3
    • 3
    • 3
    Western Blotting (WB), ELISA
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP1.
    亚型
    IgG
    Top Product
    Discover our top product PPP1R13B Primary Antibody
  • 应用备注
    This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 120 kDa in size corresponding to ASPP1 by western blotting in the appropriate cell lysate or extract.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
    别名
    ASPP1 (PPP1R13B 产品)
    别名
    ASPP1 antibody, p53BP2-like antibody, p85 antibody, AI449786 antibody, AW545810 antibody, Tp53bp2 antibody, Trp53bp2 antibody, protein phosphatase 1 regulatory subunit 13B antibody, protein phosphatase 1, regulatory subunit 13B antibody, protein phosphatase 1 regulatory subunit 13B L homeolog antibody, protein phosphatase 1, regulatory subunit 13Bb antibody, protein phosphatase 1, regulatory (inhibitor) subunit 13B antibody, PPP1R13B antibody, Ppp1r13b antibody, ppp1r13b.L antibody, ppp1r13bb antibody, ppp1r13b antibody
    背景
    ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
    Synonyms: p53BP2 like antibody, p85 antibody, PPP1R13B antibody
    基因ID
    23368, 121114287
    UniProt
    Q62415
    途径
    p53 Pathway
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