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PPP1R13B 抗体

PPP1R13B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN233830
发货至: 中国
  • 抗原 See all PPP1R13B 抗体
    PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
    适用
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    宿主
    • 44
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    克隆类型
    • 44
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    多克隆
    标记
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    This PPP1R13B antibody is un-conjugated
    应用范围
    • 32
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    Western Blotting (WB), ELISA
    原理
    ASPP1 Antibody
    交叉反应 (详细)
    This affinity purified antibody is directed against human ASPP1.
    产品特性
    Synonyms: rabbit anti-ASPP1 Antibody, ASPP-1, ASPP 1, p53BP2 like antibody, p85 antibody, PPP1R13B antibody
    纯化方法
    The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
    过滤
    Sterile filtered
    免疫原

    Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of human ASPP1.

    Immunogen Type: Conjugated Peptide

    亚型
    IgG
    Top Product
    Discover our top product PPP1R13B Primary Antibody
  • 应用备注

    Application Note: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 120 kDa in size corresponding to ASPP1 by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:500 - 1:3,000

    ELISA Dilution: 1:2,500 - 1:10,000

    Other: User Optimized

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    有效期
    12 months
  • 抗原
    PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))
    别名
    PPP1R13B (PPP1R13B 产品)
    背景
    Background: ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
    基因ID
    23368
    NCBI登录号
    NP_056131
    UniProt
    Q96KQ4
    途径
    p53 Pathway
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