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ROCK2 抗体 (pTyr256)

Name: ROCK2 抗体 (pTyr256)
Brand: antibodies-online
SKU: ABIN233829
Availability: OutOfStock

ROCK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot using affinity purified anti-ROCK-2 pY256 antibody shows detection of phosphorylated ROCK-2 in transfected 293T cells. (ROCK2 抗体 (pTyr256))

1 image

(1 reference)

产品编号 ABIN233829

发货至: 中国

Datasheet as PDF

抗原 See all ROCK2 抗体

ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))
抗原表位
15

15

9

8

7

7

6

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr256
适用
102

65

64

4

4

3

3

2

2

1

1

1

1
人
宿主
97

5

1
兔
Compatible Secondaries
克隆类型
96

7
多克隆
标记
44

7

5

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2
This ROCK2 antibody is un-conjugated
应用范围
71

33

27

27

19

16

12

10

9

4

1

1

1

1

1
Western Blotting (WB), ELISA

产品特性

Concentration Definition: by UV absorbance at 280 nm

免疫原

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Y256 of human ROCK-2.

亚型

IgG

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anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1388) antibody
ROCK2 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 1E12 unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) antibody
KO Validated ROCK2 适用: 人 WB, IP, IHC (p), IF, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1001-1300) antibody
ROCK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1109-1388) antibody
ROCK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 652-923) antibody
ROCK2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1388) antibody
ROCK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A4 unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) antibody
ROCK2 适用: 人 WB, ELISA, IF 宿主: 兔 Monoclonal 10E1 unconjugated Recombinant Antibody

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (N-Term) antibody
ROCK2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1389) antibody
ROCK2 适用: 人 WB, ELISA, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 1E12 unconjugated

应用备注

This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 164 kDa in size corresponding to phosphorylated ROCK-2 by western blotting in the appropriate cell lysate or extract. This phospho-specific polyclonal antibody reacts with human ROCK-2 pY256 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C
Akhtar, Yousif, Dhaunsi, Sarkhouh, Chandrasekhar, Attur, Benter: "Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction." in: PLoS ONE, Vol. 8, Issue 6, pp. e67813, (2017) (PubMed).
抗原

ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

别名

Rock-2 (ROCK2 产品)

别名

rocka-a antibody, xROK antibody, rock2 antibody, rok2 antibody, ROCK2 antibody, B230113H15Rik antibody, ROKalpha antibody, Rho-kinase antibody, Rock-II antibody, Rock2m antibody, mKIAA0619 antibody, ROCK-II antibody, ROK antibody, Rho-associated, coiled-coil containing protein kinase 2 L homeolog antibody, rho-associated, coiled-coil containing protein kinase 2a antibody, Rho associated coiled-coil containing protein kinase 2 antibody, Rho-associated, coiled-coil containing protein kinase 2 antibody, Rho-associated coiled-coil containing protein kinase 2 antibody, rock2.L antibody, rock2a antibody, ROCK2 antibody, Rock2 antibody

背景

This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphological changes, a process regulated by Rho GTPases. Increased levels of RhoA or RhoC, as well as the Rho effector proteins ROCK-1 or ROCK-2, were observed in various human carcinomas. In vivo studies have also shown that ROCK inhibition reduced the invasiveness of several tumor cell lines. It is suggested that Rho and ROCK signaling contribute to the morphological changes and metastatic behavior of some tumor cells. Thus, elevated Rho and ROCK expression is associated with tumorigenesis, particularly during the progression to invasive and metastatic phenotypes. Phosphorylation of certain residues in ROCK-2 may be critical for its kinase activity.
Synonyms: Rho-associated protein kinase 2 EC=2.7.11.1 Rho-associated, coiled-coil-containing protein kinase 2 p164 ROCK-2 Rho kinase 2

基因ID

9475, 4520225

UniProt

O75116

途径

Microtubule Dynamics, WNT signaling, Tube Formation