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Tamalin/GRASP 抗体

GRASP 适用: 小鼠 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN233820
发货至: 中国
  • 抗原 See all Tamalin/GRASP (GRASP) 抗体
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    适用
    • 17
    • 16
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 18
    克隆类型
    • 18
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Tamalin/GRASP antibody is un-conjugated
    应用范围
    • 9
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    产品特性
    Concentration Definition: by UV absorbance at 280 nm
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein.
    亚型
    IgG
    Top Product
    Discover our top product GRASP Primary Antibody
  • 应用备注
    This affinity purified antibody has been tested for use in ELISA, western blotting, and immunoprecipitation.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 42 kDa in size corresponding to Tamalin protein by western blotting in the appropriate cell lysate or extract.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.03 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • Kimura, Kitano, Nakajima, Nakanishi: "Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 7, pp. 631-40, (2004) (PubMed).

    Hirose, Kitano, Nakajima, Moriyoshi, Yanagi, Yamamura, Muto, Jingami, Nakanishi: "Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32308-15, (2004) (PubMed).

    Kitano, Nishida, Itsukaichi, Minami, Ogawa, Hirano, Mori, Nakanishi: "Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 25101-8, (2003) (PubMed).

    Kitano, Kimura, Yamazaki, Soda, Shigemoto, Nakajima, Nakanishi: "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 4, pp. 1280-9, (2002) (PubMed).

  • 抗原
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    别名
    Tamalin (GRASP 产品)
    别名
    GRASP antibody, tamalin antibody, TAMALIN antibody, general receptor for phosphoinositides 1 associated scaffold protein antibody, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein antibody, GRASP antibody, grasp antibody, Grasp antibody
    背景
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domain-containing protein that interacts with group 1 metabotropic glutamate receptors (mGluRs).  The PDZ domain-containing amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs.  The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins.  Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins.  It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.
    Synonyms: DXImx47e antibody, GRASP 1 antibody, GRIP 1 associated protein 1 antibody, GRIP associated protein 1 antibody, GRIP1 associated protein 1 antibody, GRIPAP 1 antibody, General receptor for phosphoinositides 1-associated scaffold protein
    基因ID
    56149, 103472019
    UniProt
    Q9JJA9
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