(1 reference)-
- 抗原 See all CHID1 抗体
- CHID1 (Chitinase Domain Containing 1 (CHID1))
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适用
- 人
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CHID1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 1C11
- Top Product
- Discover our top product CHID1 Primary Antibody
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anti-Chitinase Domain Containing 1 (CHID1) (AA 20-393) antibody
CHID1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chitinase Domain Containing 1 (CHID1) (AA 81-130) antibodyCHID1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chitinase Domain Containing 1 (CHID1) antibodyCHID1 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chitinase Domain Containing 1 (CHID1) (AA 1-393) antibodyCHID1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." in: Blood, Vol. 107, Issue 8, pp. 3221-8, (2006) (PubMed).
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: "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." in: Blood, Vol. 107, Issue 8, pp. 3221-8, (2006) (PubMed).
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- 抗原
- CHID1 (Chitinase Domain Containing 1 (CHID1))
- 别名
- Stabilin-1 Interacting Chitinase-Like Protein (CHID1 产品)
- 别名
- CHIL1 antibody, MGC84097 antibody, MGC89312 antibody, SI-CLP antibody, 3110023E09Rik antibody, AI841869 antibody, Cc1-9 antibody, RGD1308955 antibody, fb02e07 antibody, wu:fb02e07 antibody, zgc:66396 antibody, chitinase domain containing 1 antibody, chitinase domain containing 1 L homeolog antibody, CHID1 antibody, chid1.L antibody, chid1 antibody, Chid1 antibody
- 背景
- The monoclonal antibody 1C11 recognizes human stabilin-1 interacting chitinase-like protein (SI-CLP). SI-CLP is a 39 kD member of the family of Glyco_18-domain-containing proteins. These chitinase-like proteins are involved primarily in Th2-associated disorders and tumor progression. Chitinase-like proteins are soluble mediators of cell differentiation, proliferation, activation, migration, and adherence. Chitinase like protein SI-CLP is a stabilin-1 interacting partner. SI-CLP gene expression was up- regulated by IL-4 and dexamethasone on the mRNA and protein levels in primary human macrophages in parallel with the expression of stabilin-1. The major site of SI-CLP intracellular localization is in Lamp1-positive and secretion commited CD63+ secretory lysosomes. The endocytic/sorting receptor stabilin-1 is a highly specific intracellular sorting receptor for SI-CLP. SI-CLP directly binds to, and colocalizes with stabilin-1. The lysosomal localization of SI-CLP in stabilin-1-negative macrophages, however, indicates that stabilin-1 may not be the only receptor mediating trafficking of newly synthesized SI-CLP. In vivo, the monoclonal antibody 1C11 recognizes SI-CLP in the cellular fraction of bronchoalveolar lavage specimens obtained from patients with chronic inflammatory disorders of the respiratory tract and in peripheral-blood leukocytes (PBLs) from these patients as well as healthy donors. Immunogen Amino acids 24 to 73 fragment GST-fusion protein Rat IgG2a
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