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JAML 抗体

AMICA1 适用: 人 WB, FACS, IF, IP 宿主: 小鼠 Monoclonal BV16 unconjugated
产品编号 ABIN2192220
发货至: 中国
  • 抗原 See all JAML (AMICA1) 抗体
    JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))
    适用
    • 28
    • 2
    宿主
    • 18
    • 7
    • 3
    • 2
    小鼠
    克隆类型
    • 22
    • 7
    单克隆
    标记
    • 15
    • 4
    • 3
    • 3
    • 3
    • 2
    This JAML antibody is un-conjugated
    应用范围
    • 27
    • 22
    • 8
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
    过滤
    0.2 μm filtered
    克隆位点
    BV16
    Top Product
    Discover our top product AMICA1 Primary Antibody
  • 应用备注
    It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • Vetrano, Rescigno, Cera, Correale, Rumio, Doni, Fantini, Sturm, Borroni, Repici, Locati, Malesci, Dejana, Danese: "Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease." in: Gastroenterology, Vol. 135, Issue 1, pp. 173-84, (2008) (PubMed).

    Luo, Zhuo, Fukuhara, Rizzolo: "Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line." in: Investigative ophthalmology & visual science, Vol. 47, Issue 8, pp. 3644-55, (2006) (PubMed).

    Faure, Cerini, Paul, Berland, Dignat-George, Brunet: "The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro." in: International immunology, Vol. 18, Issue 10, pp. 1453-9, (2006) (PubMed).

    Bazzoni, Martinez-Estrada, Orsenigo, Cordenonsi, Citi, Dejana: "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20520-6, (2000) (PubMed).

  • 抗原
    JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))
    别名
    Junctional Adhesion Molecule (AMICA1 产品)
    别名
    RGD1562572 antibody, AMICA antibody, CREA7-1 antibody, CREA7-4 antibody, Gm638 antibody, JAML antibody, Crea7 antibody, junction adhesion molecule like antibody, Jaml antibody, JAML antibody
    背景
    The monoclonal antibody BV16 recognizes the human junction adhesion molecule (JAM)-A. Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the beta2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role for JAM-A in the initiation of atherosclerosis since JAM-A is upregulated on early atherosclerotic endothelium. The adhesion of activated platelets on the activated endothelium is mediated by homophilic interactions of JAM-A. PAM-1, JAM-1, JAMA, CD321, platelet F11 receptor Aliases Fusion protein consisting of the extracellular domain of human JAM and the Fc portion of human IgGs Immunogen Mouse IgG1
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