C1q 抗体
C1q
适用: 大鼠
IHC (fro), IP, IA
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all C1q 抗体
- C1q (Complement Fragment C1q (C1q))
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This C1q antibody is un-conjugated
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应用范围
- Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- Top Product
- Discover our top product C1q Primary Antibody
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- 应用备注
- For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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- 抗原
- C1q (Complement Fragment C1q (C1q))
- 别名
- c1q (C1q 产品)
- 别名
- AI255395 antibody, C1q antibody, complement component 1, q subcomponent, alpha polypeptide antibody, C1qa antibody
- 背景
- The polyclonal antibody recognizes rat C1q, a 459 kDa molecule consisting of three individual polypeptide chains. C1q composes together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). Aliases 11S protein
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